Results 11 to 20 of about 330,080 (279)
Metabolic syndrome and the immunologic affair with the blood-brain barrier [PDF]
Frontiers in Immunology, 2015 Epidemiological studies reveal an increased incidence of obesity worldwide, which is associated with increased prevalence and severity of cognitive disorders.
Claudio eMauro +3 more
doaj +8 more sources
Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue [PDF]
Frontiers in Cellular Neuroscience, 2014 Drug biotransformation is a crucial mechanism for facilitating the elimination of chemicals from the organism and for decreasing their pharmacological activity. Published evidence suggests that brain drug metabolism may play a role in the development of adverse drug reactions and in the clinical response to drugs and xenobiotics.
José A.G. Agúndez +5 more
openaire +4 more sources
The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy
Pharmaceuticals, 2023 Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for Alzheimer’s disease (AD) but has limited blood–brain barrier (BBB) permeability. EPO fused to a chimeric transferrin receptor monoclonal antibody (cTfRMAb) enters the brain via TfR-mediated transcytosis across the BBB.
Joshua Yang +7 more
openaire +4 more sources
The role of the blood–brain barrier in the development and treatment of migraine and other pain disorders [PDF]
Frontiers in Cellular Neuroscience, 2014 The function of the blood-brain barrier (BBB) related to chronic pain has been explored for its classical role in regulating the transcellular and paracellular transport, thus controlling the flow of drugs that act at the central nervous system, such as opioid analgesics (e.g., morphine) and non-steroidal anti-inflammatory drugs.
Marcos Fabio DosSantos +7 more
openaire +4 more sources
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice
Journal of Experimental Medicine, 2022 Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer’s disease, leads to blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction predicts cognitive decline and precedes synaptic deficits in APOE4 human carriers. How APOE4 affects BBB and synaptic function at a molecular level, however, remains elusive. Using
Giuseppe Barisano +12 more
openaire +3 more sources
Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice [PDF]
Fluids and Barriers of the CNS, 2021 Abstract Background Destruction of blood–brain barrier (BBB) is one of the main mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Frizzled-7 is a key protein expressed on the surface of endothelial cells that controls vascular permeability through the Wnt-canonical pathway involving WNT1 ...
Wei He +8 more
openaire +4 more sources
Selective Disruption of the Blood–Brain Barrier by Zika Virus [PDF]
Frontiers in Microbiology, 2019 The blood-brain barrier (BBB) selectively regulates the cellular exchange of macromolecules between the circulation and the central nervous system (CNS). Here, we hypothesize that Zika virus (ZIKV) infects the brain via a disrupted BBB and altered expression of tight junction (TJ) proteins, which are structural components of the BBB.
Leda, Ana Rachel +5 more
openaire +5 more sources
In vitro Models of the Human Blood–Brain Barrier and the Impact of Efflux Transporters on Neurological Disorders: The Work of Cioni et al. (2012) [PDF]
Frontiers in Psychiatry, 2014 The blood–brain barrier (BBB) plays a fundamental role in the integrity of brain homeostasis. Acute disruption and also even slight shifting of equilibrium of structural elements or transport processes might lead to substantial consequences, resulting in neurological disorders (1).
Gabriele Jedlitschky, Silke Vogelgesang
openaire +3 more sources
Scientific Reports, 2022 AbstractThe Blood–Brain Barrier (BBB) is a highly-selective physiologic barrier responsible for maintaining cerebral homeostasis. Innovative in vitro models of the BBB are needed to provide useful insights into BBB function with CNS disorders like traumatic brain injury (TBI).
Bolden, Christopher T +6 more
openaire +3 more sources
Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier [PDF]
Cell Transplantation, 2014 Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including
Gonzales-Portillo, Gabriel S. +7 more
openaire +5 more sources