Results 11 to 20 of about 700,460 (319)

Dissecting gene expression at the blood-brain barrier [PDF]

Frontiers in Neuroscience, 2014
The availability of genome-wide expression data for the blood-brain barrier is an invaluable resource that has recently enabled the discovery of several genes and pathways involved in the development and maintenance of the blood-brain barrier ...
Melanie A Huntley, Nga eBien-Ly, Richard eDaneman, Ryan J Watts   +3 more
doaj   +6 more sources

Real-time monitoring of human blood-brain barrier disruption [PDF]

, 2017
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma.
Alahuhta, Seppo, Isokangas, Matti, Keinanen, Tuija, Kiviniemi, Vesa, Korhonen, Vesa, Kortelainen, Jukka, Kuittinen, Outi, Myllyla, Teemu, Nikkinen, Juha, Rytky, Seppo, Siniluoto, Topi, Sonkajarvi, Eila, Tervonen, Osmo, Tuovinen, Timo, Turpeenniemi-Hujanen, Taina, Voipio, Juha   +15 more
core   +10 more sources

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source

Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]

, 2017
Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E., Brailoiu, Eugen, Brailoiu, G. Cristina, Shipsky, Megan M., Yan, Guang   +4 more
core   +2 more sources

Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis

Neurobiology of Disease, 2017
Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is a neuroinflammatory, demyelinating disease widely recognized as an animal model of multiple ...
Bandana Shrestha, Xi Jiang, Shujun Ge, Debayon Paul, Peter Chianchiano, Joel S. Pachter   +5 more
doaj   +1 more source

Translocating the blood-brain barrier using electrostatics [PDF]

, 2012
Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the ...
Castanho, Miguel A. R. B., Domingues, Marco M., Freire, João M., Ribeiro, Marta M. B., Santos, Nuno C.   +4 more
core   +2 more sources

Structure and function of the blood–brain barrier

Neurobiology of Disease, 2010
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood–brain barrier (BBB), blood–CSF barrier and the arachnoid barrier.
N. Joan Abbott, Adjanie A.K. Patabendige, Diana E.M. Dolman, Siti R. Yusof, David J. Begley   +4 more
doaj   +1 more source

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Frontiers in Cell and Developmental Biology, 2023
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu, Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Lu Chen, Wanlin Ye, Wanlin Ye, Yi Kang, Yi Kang, Guo Chen, Guo Chen, Tao Zhu, Tao Zhu   +13 more
doaj   +1 more source

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source