Results 21 to 30 of about 700,460 (319)

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S., Jayasekera, S., Khan, Naveed Ahmed, Kim, K.S., Sissons, J., Stins, M.   +5 more
core   +3 more sources

Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier [PDF]

, 2015
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and ...
Asgari, Nasrin, Berg, Carsten Tue, Khorooshi, Reza, Mørch, Marlene Thorsen, Owens, Trevor   +4 more
core   +2 more sources

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source

MOESM1 of Kv1.3 channel blocker (ImKTx88) maintains bloodâ brain barrier in experimental autoimmune encephalomyelitis

, 2017
Additional file 1: Tables S1. ImKTx88 reduces clinical signs in EAE rats.
Huang, Jie, Han, Song, Sun, Qi, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Yin, Jun, Xiaohua He   +10 more
openaire   +1 more source

The restorative role of annexin A1 at the blood–brain barrier [PDF]

, 2016
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the
A Aggarwal, A Algotsson, A Armulik, A Cignarella, A Kosicka, A Mahringer, A Moheet, A Montagne, A Parimisetty, A Razmara, A Rosell, A Varatharaj, AB Mitchell, ACC Fonseca da, AJ Farrall, AJ Kiliaan, AK Deo, AK Harris, AM Stranahan, AMS Hartz, AMS Hartz, AP Viggars, AR Nelson, B Engelhardt, B Engelhardt, B Harten van, B Obermeier, B Shao, B Stieger, B-O Nilsson, BJ Andreone, BL Hart, BO Popescu, BT Hawkins, BV Zlokovic, BW Chow, BW McColl, C Derada Troletti, C Joseph, C Knott, C Moran, C Wang, CA Raji, CE Tagoe, CH Hillman, CJ Ek, CN Hall, CV Carman, CW D’Acunto, D Virgintino, D Virgintino, DA Eberhard, DR Thal, DW Kim, DY Yoo, E Brailoiu, E Cristante, E Duinkerken Van, E Maggioli, E Pietronigro, E Solito, E Zenaro, F Boraldi, F Bruschi, F Shimizu, FN Doubal, FNE Gavins, FR Walter, G Cheng, G Cirino, G Fredman, G Han, G Leoni, GG Ortiz, GJ Zoppo del, GL Bowman, H Kang, H Kim, H Qosa, H Sun, H Wang, HJ Haar van de, HK Smith, HS Kang, IA Simpson, J Deng, J Guo, J Satoh, J Tu, J-H Liu, JA Shin, JA Shin, JD Sengillo, JH Heo, JI Alvarez, JM Wardlaw, JS Saczynski, K Monastyrskaya, KM Thrailkill, L Bloemendaal van, L Nathan, L Parente, L Raz, L Sanchez-Covarrubias, L Zhou, L-C Chen, LA Profenno, LB Buckman, LD Ghitescu, M Asgari, M Brkic, M Burek, M Burek, M Elahy, M Fuente de la, M Hellström, M Perretti, M Perretti, M Schwaninger, MA Lopez-Ramirez, MA Lopez-Ramirez, MS Thomsen, N Gorlé, N Muradashvili, N Pannacciulli, N Sumi, NJ Abbott, NJ Abbott, NJ Abbott, NR Saunders, NT Pietrani, P Hu, PJ Magistretti, Q-H Liu, R Deane, R Hallmann, R Sankowski, RC Janzer, RD Bell, RF Haseloff, RH McCusker, RO Roberts, RT Kovacic, S Bena, S Burgmans, S Liebner, S Maysami, S McArthur, S Nadkarni, S Nourshargh, S Ouyang, S Probst-Cousin, S Rius-Pérez, S Suzuki, S Taheri, S Tietz, S Wang, SA Vital, SE Headland, SE Kanoski, SE Moss, SN Cooray, T Nishioku, TL Davidson, TO Price, TS Salameh, WS Hoogenboom, Y Luo, Y Yao, Y-F Tu, YH Jing, YH Lee, Z Tucsek, ZZ Luo   +173 more
core   +4 more sources

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V

Molecules, 2015
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch, Jorick Vanbeselaere, Clément P. Delannoy, Aurore Drolez, Caroline Mysiorek, Yann Guérardel, Philippe Delannoy, Sylvain Julien   +7 more
doaj   +1 more source

Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent [PDF]

, 2009
Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a ‘species barrier’ on interspecies experiments.
Card, Cotran, Detwiler, Foster, Foster, Fraser, Goldmann, González, González, Hamir, Hamir, Hamir, Houston, Houston, Houston, Hunter, Jeffrey, McLennan, Nakaoke, Outram, Weller, Zakharov   +21 more
core   +1 more source

Cannabinoids, Blood–Brain Barrier, and Brain Disposition

Pharmaceutics, 2020
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai, Luigi Cardia, Emanuela Elisa Sorbara, Michele Navarra, Sebastiano Gangemi, Gioacchino Calapai, Carmen Mannucci   +6 more
doaj   +1 more source

MOESM1 of Accelerated differentiation of human induced pluripotent stem cells to bloodâ brain barrier endothelial cells

, 2017
Additional file 1. Additional characterization of iPSC-derived BMECsâ primary antibody and secondary antibody information, including recognized antigen, clone, vendor, and dilution, are listed in Tables S1 and S2, respectively. Immunocytochemical analysis of astrocytes and pericytes used in co-culture experiment are shown in Figure S1.
Hollmann, Emma, Bailey, Amanda, Archit Potharazu, M. Neely, Bowman, Aaron, Lippmann, Ethan   +5 more
openaire   +1 more source