Results 31 to 40 of about 674,412 (272)

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Journal of Neuroinflammation, 2023
Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML).
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt   +8 more
doaj   +1 more source

MOESM1 of Human ES-derived MSCs correct TNF-Îą-mediated alterations in a bloodâ brain barrier model

, 2019
Additional file 1: Table S1. List qRT-PCR human primer sequences.
Ge, Shujun, Jiang, Xi, Paul, Debayon, Song, Li, Wang, Xiaofang, Pachter, Joel   +5 more
openaire   +1 more source

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]

, 2016
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk, Cheng W., Helga E. Vries, Heusschen R., Ignacio Andres Romero, Miguel Alejandro Lopez‐Ramirez, Waig S.   +6 more
core   +3 more sources

Additional file 1: of Mesenchymal stem cells decrease bloodâ brain barrier permeability in rats with severe acute pancreatitis

, 2019
Table of primers. (DOCX 15 kb)
Ronggui Lin, Li, Ming, Meiqin Luo, Tianhong Teng, Pan, Yu, Heguang Huang   +5 more
openaire   +1 more source

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

MOESM1 of The role of mutations associated with familial neurodegenerative disorders on bloodâ brain barrier function in an iPSC model

, 2019
Additional file 1: Figure S1. Phase images of differentiation of iPSCs. Figure S2. Western blots. Figure S3. Expression of individual proteins and genes across all disease lines. Figure S4. Protein and gene expression by disease. Figure S5. Gene expression normalized to WT2 and iPS12 lines. Figure S6. Additional stains: ZO-1. Figure S7.
Katt, Moriah, Lakyn Mayo, Ellis, Shannon, Mahairaki, Vasiliki, Rothstein, Jeffrey, Linzhao Cheng, Searson, Peter   +6 more
openaire   +1 more source

Focused ultrasound-enabled brain tumor liquid biopsy [PDF]

, 2018
Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors.
Chen, Hong, Cheng, Galen, Dunn, Gavin P., Leuthardt, Eric C., Liu, Weijun, Nazeri, Arash, Petti, Allegra A., Wang, Xiaowei, Ye, Dezhuang, Yue, Yimei, Zhu, Lifei   +10 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

MOESM1 of Modeling and rescue of defective bloodâ brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients

, 2018
Additional file 1: Table S1. Information on induced pluripotent stem cell (iPSC) lines used in study. Table S2. Primary antibodies used for immunocytochemistry. Table S3. Secondary antibodies used for immunocytochemistry. Table S4. Primers used for RT-PCR. Figure S1. Polymer characterization data. Figure S2. Representative immunocytochemistry images of
Lee, Catherine, Seo, Hannah, Armien, Anibal, Bates, Frank, Tolar, Jakub, Azarin, Samira   +5 more
openaire   +1 more source

Age-related changes in blood-brain barrier integrity in C57BL/6J mice [PDF]

, 2013
The blood-brain barrier (BBB) is formed by the endothelial cells of the brain microvasculature, which control the molecular traffic between the blood and brain to maintain the neural ...
Romero, I. A., Saffrey, M. J., Wang, C.
core