Results 31 to 40 of about 700,460 (319)

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Journal of Neuroinflammation, 2023
Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML).
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt   +8 more
doaj   +1 more source

MOESM1 of Human ES-derived MSCs correct TNF-Îą-mediated alterations in a bloodâ brain barrier model

, 2019
Additional file 1: Table S1. List qRT-PCR human primer sequences.
Ge, Shujun, Jiang, Xi, Paul, Debayon, Song, Li, Wang, Xiaofang, Pachter, Joel   +5 more
openaire   +1 more source

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier [PDF]

, 2016
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-beta (A beta) brain accumulation and drives ...
Alessandro Di Spiezio, Axel Heimann, Bell, Bouter, Bu, Carsten Korth, Claus U. Pietrzik, Deane, Deane, Dodart, Hahn, Heyser, Ingrid Prikulis, Ito, Ito, Ito, Julius N. Meißner, Julius Nahrath, Kanekiyo, Korth, Leneuve, Markus Schwaninger, Mc Donald, Nils Schubert, Qosa, Roosmarijn E. Vandenbroucke, Sabrina Meister, Sandra Baches, Sascha Weggen, Steffen E. Storck, Thomas A. Bayer, Tooyama, Tooyama, Wolf, Yvonne Bouter   +34 more
core   +2 more sources

Additional file 1: of Mesenchymal stem cells decrease bloodâ brain barrier permeability in rats with severe acute pancreatitis

, 2019
Table of primers. (DOCX 15 kb)
Ronggui Lin, Li, Ming, Meiqin Luo, Tianhong Teng, Pan, Yu, Heguang Huang   +5 more
openaire   +1 more source

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]

, 2016
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk, Cheng W., Helga E. Vries, Heusschen R., Ignacio Andres Romero, Miguel Alejandro Lopez‐Ramirez, Waig S.   +6 more
core   +3 more sources

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Adamson, Barreiro, Barreiro, Butcher, Carman, Carman, Carson, Celli, Christine Rampon, Cicmil, Doulet, Durieu-Trautmann, Engelhardt, Etienne, Etienne, Etienne-Manneville, Federici, Gopalakrishnan, Graesser, Gratzinger, Greenwood, Greenwood, Henshall, Hoffmann, Ilan, Jackson, Jean-Pierre Couty, John Greenwood, Kontaridis, Lacalle, Marie-Pierre Laran-Chich, Masuda, Mathilde Leveque, Millan, Muller, Newman, Newman, Patil, Pierre-Olivier Couraud, Pluskota, Reid, Rivard, Roux, Sander, Sandrine Bourdoulous, Schenkel, Schoenwaelder, Schweitzer, Shaw, Viegas, Walters, Wang, Yang, Yang   +53 more
core   +2 more sources

MOESM1 of The role of mutations associated with familial neurodegenerative disorders on bloodâ brain barrier function in an iPSC model

, 2019
Additional file 1: Figure S1. Phase images of differentiation of iPSCs. Figure S2. Western blots. Figure S3. Expression of individual proteins and genes across all disease lines. Figure S4. Protein and gene expression by disease. Figure S5. Gene expression normalized to WT2 and iPS12 lines. Figure S6. Additional stains: ZO-1. Figure S7.
Katt, Moriah, Lakyn Mayo, Ellis, Shannon, Mahairaki, Vasiliki, Rothstein, Jeffrey, Linzhao Cheng, Searson, Peter   +6 more
openaire   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

MOESM1 of Modeling and rescue of defective bloodâ brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients

, 2018
Additional file 1: Table S1. Information on induced pluripotent stem cell (iPSC) lines used in study. Table S2. Primary antibodies used for immunocytochemistry. Table S3. Secondary antibodies used for immunocytochemistry. Table S4. Primers used for RT-PCR. Figure S1. Polymer characterization data. Figure S2. Representative immunocytochemistry images of
Lee, Catherine, Seo, Hannah, Armien, Anibal, Bates, Frank, Tolar, Jakub, Azarin, Samira   +5 more
openaire   +1 more source