Results 201 to 210 of about 3,850,623 (241)

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Compare Serum VCAM‐1, NSE, Procalcitonin in Predict Sepsis Induced Encephalopathy in Septic Patients

Journal of Clinical Laboratory Analysis, EarlyView.
Serum VCAM‐1 is associated with septic encephalopathy in the first 7 days of sepsis. NSE and procalcitonin were not associated with septic encephalopathy. ABSTRACT Background Sepsis‐associated encephalopathy (SAE) is a common complication of severe sepsis. Increased concentration of Vascular Cell Adhesion Molecule 1 (VCAM‐1) is associated with SAE in a
Chun‐Fu Lin, Cheng‐Hsien Lu, Chih‐Min Su   +2 more
wiley   +1 more source

Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Kun Wang, Jiahe Wang, Ziyu Diao, Xin Tan, Shijun Qiu, Jie An   +5 more
wiley   +1 more source

Associations between intake of vitamins E and A and serum concentrations in preterm infants: A retrospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Infants in neonatal intensive care are at risk of both deficiency and excess of fat‐soluble vitamins, particularly E and A, due to limited reserves and the need for prolonged intravenous nutrition. We aimed to determine the effects of increased intravenous vitamin intake and to characterise the relationships between vitamin intake ...
A. Bronnert, L. Kremer, JE Harding, FH Bloomfield, B. E. Cormack   +4 more
wiley   +1 more source

Gamma‐glutamyltransferase and immunoglobulin G in intestinal maturation: Pilot study in preterm and term infants and the influence of breast milk

JPGN Reports, EarlyView.
Abstract Gamma‐glutamyltransferase (γGT), a key enzyme in glutathione metabolism, is abundant in colostrum and may indicate neonatal gastrointestinal maturation, although normative serum values and associations with breast milk intake remain unclear, particularly in preterm infants.
Johanna Jakobs, Teresa Riedl‐Seifert, Franziska Jakobs, Markus Waitz, Andreas Jenke   +4 more
wiley   +1 more source

Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: A systematic review and meta‐analysis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuronal loss driven by oxidative stress and inflammation. Quercetin, a dietary flavonoid with established antioxidant and anti‐inflammatory properties, has emerged as a potential neuroprotective agent.
In Ho Cho, Hendra Mahakam Putra, Cheol Woon Jung, Gyu Hwan Hyun, Hwan‐Hee Jang, In Guk Hwang, Sung Won Kwon   +6 more
wiley   +1 more source

Combined effects of kombucha consumption and aerobic exercise on oxidative stress and metabolic parameters in Wistar rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Kombucha, a fermented tea containing symbiotic bacteria and yeast, and aerobic exercise each confer distinct health benefits, but their combined effects remain poorly understood. This study investigated the combined effects of consuming kombucha fermented for 7 days and performing moderate aerobic exercise on physiological outcomes ...
Jean Carlos Costa Nogueira, Luis Paulo Santos Ribas, Raquel Moura, Jean Ramos Boldori, Alexsander Pedroso Garcia, Kaueli Rodrigues Amaral, Franciele Aline Smaniotto, Tatiana Emanuelle, Cristiane Casagrande Denardin   +8 more
wiley   +1 more source

Blood to cerebrospinal fluid barrier in spontaneous hypertension and ventricular dilation

Cerebrospinal Fluid Research, 2009
de Paz-Carmona Hector, Castañeyra-Ruiz Agustin, Segui Maria E, Castañeyra-Ruiz Leandro, Gonzalez-Toledo Juan M, Fernández-Rodríguez Paloma, González-Marrero Ibrahim, Castañeyra-Perdomo Agustin, Hernandez-Garde Isabel, Carmona-Calero Emilia M   +9 more
doaj   +1 more source

Metabolic Syndrome and Dementia Risk in Older Adults: A Narrative Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Dementia is a major global health issue in aging societies. Metabolic syndrome (MetS), a cluster of metabolic abnormalities, has been proposed as a modifiable risk factor for dementia, although existing evidence remains inconsistent. This review examined recent studies on the association between MetS and dementia risk in older adults.
Hyojin Park, Mallika Chuansangeam, Yuan‐Han Yang   +2 more
wiley   +1 more source