Results 111 to 120 of about 966,153 (399)
Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
Frontiers in Aging Neuroscience, 2020 Alzheimer’s disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB).
W. Pardridge
semanticscholar +1 more source
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. [PDF]
, 2019 Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease.
Aydin, Sidar +16 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Walk With Ease (WWE) is a six‐week arthritis‐appropriate evidence‐based physical activity program traditionally offered in a face‐to‐face format. Because many populations encounter participation barriers to in‐person programs, WWE was modified for telephone delivery (WWE‐T).
Christine A. Pellegrini +5 more
wiley +1 more source
Measuring Blood-brain-barrier Permeability Using Evans Blue in Mice
Bio-Protocol, 2015 The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid in the central nervous system.
Jun-Xia Yang, Yan-Yu Jiang, Yu-Bai Guo
doaj +1 more source
Nature, 1977 Blood–Brain Barrier in Physiology and Medicine. By Stanley I. Rapoport. Pp. xii + 316. (Raven: New York, 1976.) $28.
openaire +1 more source
Exploring the Brainpeps database [PDF]
, 2012 Since the discovery that peptides can cross the blood-brain barrier (BBB), doors have been opened to new therapeutics for CNS diseases and pain management.
Bracke, Nathalie +4 more
core +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Barrier mechanisms in the Drosophila blood-brain barrier
Frontiers in Neuroscience, 2014 The invertebrate blood-brain barrier field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance
Samantha Jane Hindle +1 more
doaj +1 more source
Tunnelling Through Two Barriers [PDF]
arXiv, 2004 Recent studies of the tunnelling through two opaque barriers claim that the transit time is independent of the barrier widths and of the separation distance between the barriers. We observe, in contrast, that if multiple reflections are allowed for correctly (infinite peaks) the transit time between the barriers appears exactly as expected.
arxiv
Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]
, 2009 The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane +14 more
core