Results 141 to 150 of about 966,153 (399)

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma

Communications Materials
The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover ...
Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda   +5 more
doaj   +1 more source

Interaction of major facilitator superfamily domain containing 2A with the blood–brain barrier

Neural Regeneration Research
The functional and structural integrity of the blood–brain barrier is crucial in maintaining homeostasis in the brain microenvironment; however, the molecular mechanisms underlying the formation and function of the blood–brain barrier remain poorly ...
Yilun Ma, Taiwei Dong, Fei Luan, Juanjuan Yang, Feng Miao, Peifeng Wei   +5 more
doaj   +1 more source

Local time and the pricing of time-dependent barrier options [PDF]

arXiv, 2008
A time-dependent double-barrier option is a derivative security that delivers the terminal value $\phi(S_T)$ at expiry $T$ if neither of the continuous time-dependent barriers $b_\pm:[0,T]\to \RR_+$ have been hit during the time interval $[0,T]$. Using a probabilistic approach we obtain a decomposition of the barrier option price into the corresponding
arxiv  

Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury

International Journal of Molecular Sciences, 2020
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is
Alison M. Cash, M. Theus
semanticscholar   +1 more source

LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. [PDF]

, 2015
The blood-brain barrier (BBB) is a term used to describe the unique properties of central nervous system (CNS) blood vessels. One important BBB property is the formation of a paracellular barrier made by tight junctions (TJs) between CNS endothelial ...
Arnold, Thomas D, Daneman, Richard, Derugin, Nikita, Lee, Seo Yeon, Lin, Christina, Munji, Roeben N, Ruderisch, Nadine, Sohet, Fabien, Soung, Allison, Vexler, Zinaida S, Yen, Frances T   +10 more
core   +2 more sources

Synthetic Bilirubin‐Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune‐Modulating Activity

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan, Hyunjin Kim, Bomin Kim, Honglin Piao, Joon Young Jang, Tae Kyeom Kang, Wook‐Bin Lee, Dohyeon Kim, Seunghyun Jo, Duckhyang Shin, Sharif MD Abuzar, Myung L. Kim, Jaeseok Yang, Sangyong Jon   +13 more
wiley   +1 more source

Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

Neural Plasticity, 2018
Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a “neuro-glia-vascular unit,” a structural and functional compound ...
Yinan Zhao, Yanguo Xin, Zhiyi He, Wenyu Hu   +3 more
doaj   +1 more source

Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells [PDF]

, 2015
Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the blood-brain barrier, secretion of inflammatory ...
Amanda V. Steckert, Felipe Dal-Pizzol, João Quevedo, Monique Michels, Tatiana Barichello   +4 more
core   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

Gut microbes, 2019
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with the host.
Aimée Parker, S. Fonseca, S. Carding
semanticscholar   +1 more source