Results 281 to 290 of about 700,468 (343)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

microRNA-184 distribution and consequences on glial septate junctions and the blood-brain barrier. [PDF]

PLoS One
Paluri S, Auld VJ.
europepmc   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

BMSC-Derived Exosomal miR-21a-5p Ameliorates Blood-Brain Barrier Injury and Hemorrhagic Transformation. [PDF]

Mol Neurobiol
Yang J, Tang N, Dai R, Chen J, Li Z, Jiang F, Li S, Meng Q.   +7 more
europepmc   +1 more source

In Vitro Analysis of TWEAK/Fn14 Axis in the Blood-Brain Barrier Models during Oxygen-Glucose Deprivation and Reoxygenation. [PDF]

Mol Neurobiol
Sampedro-Viana A, Alonso-Alonso ML, Castillo J, Hervella P, Álvarez E, Burek M, Iglesias-Rey R.   +6 more
europepmc   +1 more source

Postulated vasoactive neuropeptide immunopathology affecting the blood–brain/blood–spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

, 2008
Sonya Marshall‐Gradisnik, Ekua Brenu, Donald Staines   +2 more
openalex   +1 more source