Results 61 to 70 of about 736,342 (305)

How anti-brain antibodies access the bran and alter behavior and cognition

Journal of Affective Disorders Reports, 2023
Antibodies can target brain antigens but are not harmful to the host unless they enter brain parenchyma. An adult human or mouse has a blood brain barrier that excludes immunoglobulin from entering brain parenchyma.
Betty Diamond, MD
doaj   +1 more source

The blood-brain barrier in systemic inflammation.

Brain, behavior, and immunity, 2017
The blood-brain barrier (BBB) plays a key role in maintaining the specialized microenvironment of the central nervous system (CNS), and enabling communication with the systemic compartment. BBB changes occur in several CNS pathologies.
A. Varatharaj, I. Galea
semanticscholar   +1 more source

Blood-Brain Barrier Genomics [PDF]

Stroke, 2007
Blood-brain barrier (BBB) genomics begins with the isolation of capillaries from fresh animal or human brain and is followed on the same day with the purification of capillary-derived RNA. The identification of microvascular-enriched genes from a whole brain gene microarray is unlikely because the brain capillary endothelial volume is <0.1% of total
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Pharmaceutics
Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption.
Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N. Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza   +10 more
doaj   +1 more source

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Fluids and Barriers of the CNS, 2018
This review considers efflux of substances from brain parenchyma quantified as values of clearances (CL, stated in µL g−1 min−1). Total clearance of a substance is the sum of clearance values for all available routes including perivascular pathways and ...
Stephen B. Hladky, Margery A. Barrand
doaj   +1 more source

Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors

Frontiers in Oncology, 2020
Recent advances in maximum safe glioma resection have included the introduction of a host of visualization techniques to complement intraoperative white-light imaging of tumors.
Evgenii Belykh, Kurt V. Shaffer, Chaoqun Lin, Vadim A. Byvaltsev, Mark C. Preul, Lukui Chen   +5 more
doaj   +1 more source

B3Pred: A Random-Forest-Based Method for Predicting and Designing Blood–Brain Barrier Penetrating Peptides

Pharmaceutics, 2021
The blood–brain barrier is a major obstacle in treating brain-related disorders, as it does not allow the delivery of drugs into the brain. We developed a method for predicting blood–brain barrier penetrating peptides to facilitate drug delivery into the
Vinod Kumar, Sumeet Patiyal, Anjali Dhall, Neelam Sharma, Gajendra Pal Singh Raghava   +4 more
doaj   +1 more source

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

ACS Nano
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels.
Shuai Zha, Haitao Liu, Hengde Li, Haolan Li, Ka-Leung Wong, A. All   +5 more
semanticscholar   +1 more source

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

Nature Communications, 2019
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this process remains unclear.
Koichiro Haruwaka, Ako Ikegami, Y. Tachibana, N. Ohno, Hiroyuki Konishi, Akari Hashimoto, Mami Matsumoto, D. Kato, Riho Ono, H. Kiyama, A. Moorhouse, J. Nabekura, H. Wake   +12 more
semanticscholar   +1 more source