Results 21 to 30 of about 17,492,293 (382)

An Erg-driven transcriptional program controls B cell lymphopoiesis

Nature Communications, 2020
B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically ...
Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander   +27 more
doaj   +1 more source

The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

BMC Cancer, 2020
Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required.
Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam, Claire H. Seedhouse   +4 more
doaj   +1 more source

Following red blood cells in a pulmonary capillary [PDF]

, 2007
The red blood cells or erythrocytes are biconcave shaped cells and consist mostly in a membrane delimiting a cytosol with a high concentration in hemoglobin.
B. Maury, B. Sapoval, Benjamin Mauroy, C. Grandmont, J.F. Gerbeau, L. Boudin, Y. Maday   +6 more
core   +2 more sources

A combination of pre-infusion serum ferritin, CRP and IL-6 predicts outcome in relapsed/refractory multiple myeloma patients treated with CAR-T cells

Frontiers in Immunology, 2023
BackgroundChimeric antigen receptor - T (CAR-T) cell therapy has shown remarkable efficacy in patients with relapsed/refractory multiple myeloma (R/R MM).
Yang Liu, Yang Liu, Yang Liu, Xingxing Jie, Xingxing Jie, Xingxing Jie, Li Nian, Li Nian, Li Nian, Ying Wang, Ying Wang, Ying Wang, Congyue Wang, Congyue Wang, Congyue Wang, Jin Ma, Jin Ma, Jin Ma, Jingjing Jiang, Jingjing Jiang, Jingjing Jiang, Qingyun Wu, Qingyun Wu, Qingyun Wu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao, Wei Chen, Wei Chen, Wei Chen, Jiang Cao, Jiang Cao, Jiang Cao, Zhiling Yan, Zhiling Yan, Zhiling Yan, Ming Shi, Hai Cheng, Hai Cheng, Hai Cheng, Feng Zhu, Feng Zhu, Feng Zhu, Wei Sang, Wei Sang, Wei Sang, Depeng Li, Depeng Li, Depeng Li, Chong Chen, Chong Chen, Chong Chen, Kailin Xu, Kailin Xu, Kailin Xu, Zhenyu Li, Zhenyu Li, Zhenyu Li   +57 more
doaj   +1 more source

Parylene membrane slot filter for the capture, analysis and culture of viable circulating tumor cells [PDF]

, 2010
This paper presents a method of capturing viable circulating tumor cells (CTC) from human whole blood using constant-pressure-driven filtration through a specially designed parylene-C membrane “slot” filter. More than 90% viable cancer cells could be
Goldkorn, Amir, Lu, Bo, Tai, Yu-Chong, Xu, Tong, Zheng, Siyang   +4 more
core   +1 more source

EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation

Frontiers in Immunology, 2022
IntroductionGraft-versus-host disease (GVHD) damages vascular endothelium. Endothelial progenitor cell (EPC) can differentiate to endothelial cell and promote angiogenesis, but its role in endothelial damage in GVHD is unclear.MethodsIn this study, we ...
Weiwei Wang, Weiwei Wang, Weiwei Wang, Yali Ye, Yali Ye, Yali Ye, Yuwei Du, Yuwei Du, Yuwei Du, Zhengqing Xu, Zhengqing Xu, Zhengqing Xu, Ke Yuan, Ke Yuan, Ke Yuan, Yizhou Wang, Yizhou Wang, Yizhou Wang, Seyram Yao Adzraku, Seyram Yao Adzraku, Seyram Yao Adzraku, Yue Li, Yue Li, Yue Li, Kailin Xu, Kailin Xu, Kailin Xu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao, Wen Ju, Wen Ju, Wen Ju, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng   +35 more
doaj   +1 more source

M-DC8+leukocytes - A novel human dendritic cell population [PDF]

, 1999
Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies.
Federle, Christine, Mayer, Elfriede, Poppe, Claudia, Rieber, Ernst Peter, Riethmüller, Gert, Schäkel, Knut   +5 more
core   +2 more sources

Immunotherapies targeting GPRC5D in relapsed or refractory multiple myeloma: latest updates from 2022 ASH Annual Meeting

Journal of Hematology & Oncology, 2023
B cell maturation antigen (BCMA)-targeted immunotherapy has shown unprecedented results in the treatment of relapsed or refractory (R/R) multiple myeloma (MM).
Jieyun Xia, Zhenyu Li, Kailin Xu
doaj   +1 more source

Red blood cells: the forgotten player in hemostasis and thrombosis

Journal of Thrombosis and Haemostasis, 2019
New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review summarizes the most recent research that describes the involvement of
J. Weisel, R. Litvinov, R. Litvinov
semanticscholar   +1 more source

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

Aging, 2018
DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts and other cell types used in ex vivo studies.
S. Horvath, J. Oshima, G. Martin, A. Lu, Austin Quach, Howard Cohen, Sarah Felton, Mieko Matsuyama, Donna J. Lowe, S. Kabacik, James G. Wilson, A. Reiner, Anna Maierhofer, Julia Flunkert, A. Aviv, L. Hou, A. Baccarelli, Yun Li, J. Stewart, E. Whitsel, L. Ferrucci, S. Matsuyama, K. Raj   +22 more
semanticscholar   +1 more source