Results 261 to 270 of about 6,572,687 (353)

Ultrasmall Enzyme-Powered Janus Nanomotor Working in Blood Circulation System.

ACS Nano, 2023
Injectable chemically powered nanomotors may revolutionize biomedical technologies, but to date, it is a challenge for them to move autonomously in the blood circulation system and they are too large in size to break through the biological barriers ...
Zili Yang, Liangmeng Wang, Zhixue Gao, Xiaomeng Hao, Ming Luo, Zi-li Yu, Jianguo Guan   +6 more
semanticscholar   +1 more source

Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance.

Journal of Controlled Release, 2023
PEGylated cholesterol-containing liposomes (Chol-PEG-lipo) have been widely used as a drug carrier for their good stealth property in blood circulation where cholesterol maintains the stability of the liposomal lipid bilayer and PEGylation endows ...
Jiaxuan Xia, Chen Chen, Meichen Dong, Ying Zhu, Anni Wang, Shiyi Li, Ru Zhang, Chunbo Feng, Xinnan Jiang, Xinchun Xu, Jianxin Wang   +10 more
semanticscholar   +1 more source

Blood Circulation Assessment by Steadily Fluorescent Near-Infrared-II Aggregation-Induced Emission Nano Contrast Agents.

ACS Nano, 2023
The dysfunction of the blood circulation system typically induces acute or chronic ischemia in limbs and vital organs, with high disability and mortality.
Rongyuan Zhang, Zhenyu Bi, Liping Zhang, Han Yang, Haoran Wang, Weijie Zhang, Zijie Qiu, Chaoji Zhang, Yu Xiong, Yuanyuan Li, Zheng Zhao, Benzhong Tang   +11 more
semanticscholar   +1 more source

Carboxybetaine-Based Zwitterionic Polymer Nanogels with Long Blood Circulation for Cancer Therapy.

Biomacromolecules, 2023
Given the advantages of antifouling capacity and good biocompatibility, zwitterionic polymers have been profoundly applied for drug delivery to improve the pharmacokinetics profile. Here, a zwitterionic polymer (poly (carboxybetaine methacrylate) (PCBMA))
Shuting Mai, Xianxian Yao, Chenzi Li, Zhiwen Yin, Minghua Zhang, Jian Xu, Zhuofan Diao, Wuli Yang   +7 more
semanticscholar   +1 more source

Polysarcosine-Coated liposomes attenuating immune response induction and prolonging blood circulation.

Journal of Colloid and Interface Science, 2023
HYPOTHESIS Liposomes coated with long polysarcosine (PSar) chains at a high density might enable long blood circulation and attenuate accelerated blood clearance (ABC) phenomenon.
Mingxin Hu, K. Taguchi, Kazuaki Matsumoto, E. Kobatake, Yoshihiro Ito, Motoki Ueda   +5 more
semanticscholar   +1 more source

Strategies for persistent retention of macromolecules and nanoparticles in the blood circulation.

Journal of Controlled Release, 2022
The enhanced permeability and retention (EPR) effect has been the gold standard in developing drug delivery systems for passive tumor targeting. Although the importance of this concept remains unchanged, some controversies have arisen.
Y. Takakura, Yuki Takahashi
semanticscholar   +1 more source

A Bright, Renal-Clearable NIR-II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging.

Angewandte Chemie, 2021
Early detection of kidney disease is of vital importance due to their current prevalence worldwide. Fluorescence imaging, especially in the second near-infrared window (NIR-II) has been regarded as a promising technique for the early diagnosis of kidney ...
Fan Zhang, Chenzhi Yao, Ying Chen, Mengyao Zhao, Shangfeng Wang, Bin Wu, Dongrui Yin, Ben Shi, Yang Yang, Ge Xu, Peng Yu, Hongxin Zhang   +11 more
semanticscholar   +1 more source

Ultrasound-Responsive Peptide Nanogels to Balance Conflicting Requirements for Deep Tumor Penetration and Prolonged Blood Circulation.

ACS Nano, 2022
A series of biological barriers need to be overcome for therapeutic nanocarriers accumulating at the tumor site and uptaken by cancer cells. One strategy is to construct switchable nanocarriers to meet the conflicting requirements for various physiology ...
Min Sun, Tao Yue, Congyu Wang, Zhen Fan, E. Gazit, Jianzhong Du   +5 more
semanticscholar   +1 more source

Triterpenoid saponins from Ilex pubescens promote blood circulation in blood stasis syndrome by regulating sphingolipid metabolism and the PI3K/AKT/eNOS signaling pathway.

Phytomedicine, 2022
BACKGROUND Blood stasis syndrome (BSS) is a severe disorder involving disturbances in glycerophosphocholine metabolism. Ilex pubescens (IP) can regulate the levels of lipids, such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE ...
Jie Chen, Di Cao, Shiqin Jiang, Xia Liu, Wencong Pan, H. Cui, Weiqun Yang, Z. Liu, Jing Jin, Zhongxiang Zhao   +9 more
semanticscholar   +1 more source

Prolonged blood circulation outperforms active targeting for nanocarriers-mediated enhanced hepatocellular carcinoma therapy in vivo.

Journal of Controlled Release, 2022
Successful hepatocellular carcinoma (HCC) therapy in vivo remains a significant challenge due to the down-regulated expression of the receptors on the surface of tumor cells for compromised active targeting efficiency and cellular uptake of nanoparticles
Yue-qing Wang, Cong Huang, Peng-Ju Ye, Jin-rong Long, Chengyuan Xu, Ying Liu, Xiao-Li Ling, Shao-Yang Lv, D. He, Hua Wei, Cuiyun Yu   +10 more
semanticscholar   +1 more source