Results 61 to 70 of about 1,345,283 (329)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The Circulatory Effects of Increased Hydrostatic Pressure Due to Immersion and Submersion

Frontiers in Physiology, 2021
Increased hydrostatic pressure as experienced during immersion and submersion has effects on the circulation. The main effect is counteracting of gravity by buoyancy, which results in reduced extravasation of fluid.
Robert P. Weenink, Robert P. Weenink, Thijs T. Wingelaar, Thijs T. Wingelaar   +3 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation

, 2009
Nanomaterials have been actively pursued for biological and medical applications in recent years. Here, we report the synthesis of several new poly(ethylene glycol) grafted branched-polymers for functionalization of various nanomaterials including carbon
Adams M. L., Ashiuchi M., Bruchez M., Chan W. C. W., Chatterjee T., Chen R. J., Chen Z., Cheng Y., Cognet L., Dieckmann G. R., Dubertret B., Fan H. Y., Gao M. Y., Gerion D., Han G., Huff T. B., Ipe B. I., Jiang W., Kam N. W. S., Kam N. W. S., Kanaras A. G., Karajanagi S. S., Kogan M. J., Kryachko E. S., Lin Wang W. Z., Liu W. H., Liu Z., Liu Z., LizMarzan L. M., Markowitz M. A., Maubach G., Mulder W. J. M., Nakayama-Ratchford N., Nam J. M., Nath N., Numata M., Oyelere A. K., O’Connell M. J., Paciotti G. F., Parveen S., Pinaud F., Porta F., Richard C., Schultz S., Selvan S. T., Sinani V. A., Sinha N., Sohn B. H., Sonnichsen C., Thaxton C. S., Tong L., Wang D., Welsher K., Williams K. A., Xiaoming Sun Z. L., Yang S. T., Zhelev Z., Zheng M., Zheng M.   +58 more
core   +1 more source

Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]

, 2017
The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka, Kwee, Ingrid L, Nakada, Tsutomu, Suzuki, Yuji   +3 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. [PDF]

, 2018
Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how
Ablooglu, Ararat J, Groisman, Alex, Gutierrez, Edgar, Saikin, Semion K, Tkachenko, Eugene, Traver, David, Weijts, Bart   +6 more
core   +3 more sources

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]

, 2015
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela, DI LOLLO, ANNA CHIARA, Gambardella, Lucrezia, Malorni, Walter, Straface, Elisabetta, Valesini, Guido   +5 more
core   +1 more source