Results 261 to 270 of about 264,190 (272)

Sustained IFN Signature Suppression with Anifrolumab in a SAVI patient Refractory to JAK Inhibitor and Dazukibart Therapy

Arthritis &Rheumatology, Accepted Article.
Objective To report the efficacy and safety of interferon‐β (IFNβ) neutralizing monoclonal antibody (dazukibart), followed by treatment with anti‐IFNAR1 antibody (anifrolumab), in a patient with STING‐associated vasculopathy with onset in infancy (SAVI) who had vasculitic ulcers and systemic inflammation refractory to Janus kinase inhibition (JAKi ...
Sara Alehashemi, Bjoern Buehring, Adriana A de Jesus, Sachin Gaurav, Andre Rastegar, Alexi Baumgardner, Kip Friend, Oluwatobi T. Arisa, William D. Figg, Danielle Fink, Douglas B. Kuhns, Ben Colton, Cody J Peer, Raphaela Goldbach‐Mansky   +13 more
wiley   +1 more source

Predictive value of blood coagulation and routine blood indices for rebleeding after endoscopic treatment in hepatitis B-related cirrhotic patients with esophagogastric fundal varices: a logistic regression model analysis. [PDF]

Am J Transl Res
Xu L, Wang P, Pan Y, Zhou X, Yin G.
europepmc   +1 more source

The role of Moringa oleifera in the development of alternative biofuels, under the concept of an integral one‐tree biorefinery: A minireview

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The Moringa oleifera oil tree is commonly known as the ‘tree of life’ or the ‘miracle tree’ owing to its multiple benefits for humans. The different parts that make up this tree (leaves, seeds and bark) have been used to treat various ailments, diseases and wounds. However, in recent years this tree is being used by the scientific community to
J. L. Aleman‐Ramirez, Patrick U. Okoye, S. Saldaña‐Trinidad, S. Torres‐Arellano, P. J. Sebastian   +4 more
wiley   +1 more source

Effects of COVID-19 infection in healthy subjects on cardiac function and biomarker of oxygen transport, blood coagulation and inflammation

, 2023
Gumanova NG, Gorshkov A, Bogdanova NL, Korolev AI.   +3 more
europepmc   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Systemic T‐cell and local macrophage interactions mediate granule size‐dependent biological hydroxyapatite foreign body reaction

BMEMat, EarlyView.
This study expanded our understanding of the size effect of biological hydroxyapatite (BHA) granules from a biological perspective rather than physical defect accommodation. Besides, we proposed the multi‐level structure of commercially available BHA granules based on their microstructure and provided a biological mechanism for the classification of ...
Yixiong Lin, Yang Zou, Jieting Yang, Zongpu Han, Xinyu Guo, Xiaomeng Gao, Jieyun Xu, Zhuohong Gong, Ruizhi Li, Zhipeng Li, Baoxin Huang, Yin Xiao, Feilong Deng, Zetao Chen   +13 more
wiley   +1 more source

Antibacterial hydrogel: The sniper of chronic wounds

BMEMat, EarlyView.
The treatment of chronic wounds has always been an important challenge in the medical field. We focus on hydrogels not only because they provide a moist healing environment but also because compared with traditional dressings, they can effectively prevent and treat infections, reduce wound pain and scar formation.
Shengtai Bian, Huijun Ye, Pan Wang, Changxing Li, Xutao Guo, Ming Guan, Shilun Feng   +6 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Blood clot inspired pore‐gradient nanofiber sponge with “outer filtration” and “inner adsorption” bifunction for rapid stop of uncontrolled hemorrhage

BMEMat, EarlyView.
In this study, by mimicking the nanofiber structure and netting blood cells function of fibrin network in blood clots, we developed a novel bioinspired quaternized chitosan nanofiber sponge with distinct blood cell filtration and blood plasma absorption bifunction for rapid hemostasis.
Fujin Zhou, Yong Yang, Yixuan Li, Ruolin Cao, Zheng Chen, Zhi Wang, Naiwen Tan, Lei Tian, Botao Song   +8 more
wiley   +1 more source