Results 21 to 30 of about 1,261,394 (292)

Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates.

Genes & Development, 1988
Delta (D1) is required for normal segregation of the embryonic ectoderm into neural and epidermal cell lineages in Drosophila melanogaster. Loss-of-function mutations in D1 and other zygotic neurogenic loci lead to expansion of the neuroblast population ...
C. Kopczynski, A. K. Alton, K. Fechtel, P. J. Kooh, M. Muskavitch   +4 more
semanticscholar   +1 more source

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study. [PDF]

, 2016
Background. Postpartum haemorrhage (PPH) is a leading cause of maternal death. Tranexamic acid (TXA) has the potential to reduce bleeding and a large randomized placebo controlled trial of its effect in women with PPH (The WOMAN trial) is underway.
Beaumont, Danielle, Cenameri, Saimir, Dallaku, Kastriot, Delius, Maria, Edwards, Phil, Gliozheni, Orion, Mansmann, Ulrich, Roberts, Ian, Shakur, Haleema, Siegmund, Braun, Tasha, Ilir   +10 more
core   +2 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris [PDF]

, 2002
Objective: To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency.
Hankey, C.R., Lean, M.E.J., Lowe, G.D.O., Rumley, A., Woodward, M.   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season [PDF]

, 2010
Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood.
Breitner, Susanne, Frampton, Mark W., Hampel, Regina, Koenig, Wolfgang, Peters, Annette, Phipps, Richard P., Rückerl, Regina, Schneider, Alexandra, Wichmann, Heinz-Erich   +8 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Molar substitution and C2/C6 ratio of hydroxyethyl starch: influence on blood coagulation [PDF]

, 2017
Background. Development of hydroxyethyl starches (HES) with a low impact on blood coagulation but a long intravascular persistence is of clinical interest.
Bombeli, T., Burmeister, M.-A, Fisch, A., Frascarolo, P., Madjdpour, C., Schramm, S., Spahn, D. R., von Roten, I.   +7 more
core  

Spatial localization of bacteria controls coagulation of human blood by ‘quorum acting' [PDF]

, 2008
Blood coagulation often accompanies bacterial infections and sepsis and is generally accepted as a consequence of immune responses. Though many bacterial species can directly activate individual coagulation factors, they have not been shown to directly
Bian, Yao, Boedicker, James Q., Ismagilov, Rustem F., Kastrup, Christian J., Kline, Timothy R., Leppla, Stephen H., Moayeri, Mahtab, Pomerantsev, Andrei P., Pompano, Rebecca R., Shen, Feng, Sylvestre, Patricia, Tang, Wei-Jen   +11 more
core   +1 more source