Results 51 to 60 of about 231,046 (311)

Cellular expression of plasma prekallikrein in human tissues [PDF]

, 2007
Plasma prekallikrein (PPK) is synthesised in hepatocytes and secreted into the blood, where it participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.
Celia Snyman, Chirurgische Klinik Innenstadt, Figueroa, Carlos D., Neth, Peter, Bhoola, Kanti D., Snyman, Celia, Edwin Fink, Carlos D. Figueroa, Peter Neth, Fink, Edwin, Kanti D. Bhoola   +10 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Association of Plasma Fibrinogen and Thromboelastography With Blood Loss in Complex Cardiac Surgery

Clinical and Applied Thrombosis/Hemostasis, 2021
Postoperative coagulopathic bleeding is common in cardiac surgery and is associated with increased morbidity and mortality. Ideally, real-time information on in-vivo coagulation should be available.
Eline A. Vlot MD, Eric P.A. van Dongen MD, PhD, Laura M. Willemsen MD, Jur M. ten Berg MD, PhD, Christian M. Hackeng IR, PhD, Stephan A. Loer MD, PhD, Peter G. Noordzij MD, PhD   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

PROTHROMBIN AND ANTITHROMBIN FACTORS IN THE COAGULATION OF BLOOD [PDF]

Archives of Internal Medicine, 1916
Few have studied the prothrombin and antithrombin factors of coagulation of the blood in human cases. Howell 1 devised methods to study these factors and has reported a deficiency of prothrombin in hemophilia with relative excess of antithrombin, a diminution of antithrombin in cases of spontaneous thrombosis and no abnormality in the cases of purpura ...
openaire   +2 more sources

Fibrin D-dimer, markers of coagulation activation and the risk of major ischaemic heart disease in the Caerphilly Study [PDF]

, 2001
We have previously reported that plasma fibrin D-dimer (a marker of turnover of cross-linked Fibrin) showed a strong and independent association with incident ischaemic heart disease (IHD) in the Caerphilly Study cohort of 1,998 men a-ed 49-65.
Lowe, G.D.O., Yarnell, J.W.G., Rumley, A., Ann Rumley, Joseph Rumley, Sweetnam, P.M., Rumley, J., Peter Sweetnam, Gordon Lowe, John Yarnell   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Honey Bee Venom (Apis mellifera) Contains Anticoagulation Factors and Increases the Blood-clotting Time

Journal of Pharmacopuncture, 2015
Objectives: Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma
Hossein Zolfagharian, Mohammad Mohajeri, Mahdi Babaie   +2 more
doaj   +1 more source

Propensity score adjusted comparison of three-factor versus four-factor prothrombin complex concentrate for emergent warfarin reversal: a retrospective cohort study

BMC Emergency Medicine, 2020
Background Prothrombin Complex Concentrates (PCC) are prescribed for emergent warfarin reversal (EWR). The comparative effectiveness and safety among PCC products are not fully understood.
David J. Margraf, Scott Seaburg, Gregory J. Beilman, Julian Wolfson, Jonathan C. Gipson, Scott A. Chapman   +5 more
doaj   +1 more source