Results 71 to 80 of about 1,225,419 (385)

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Association of Plasma Fibrinogen and Thromboelastography With Blood Loss in Complex Cardiac Surgery

Clinical and Applied Thrombosis/Hemostasis, 2021
Postoperative coagulopathic bleeding is common in cardiac surgery and is associated with increased morbidity and mortality. Ideally, real-time information on in-vivo coagulation should be available.
Eline A. Vlot MD, Eric P.A. van Dongen MD, PhD, Laura M. Willemsen MD, Jur M. ten Berg MD, PhD, Christian M. Hackeng IR, PhD, Stephan A. Loer MD, PhD, Peter G. Noordzij MD, PhD   +6 more
doaj   +1 more source

The role of neutrophil extracellular traps in thrombosis

Медицина неотложных состояний, 2023
According to the cellular model of hemostasis, the process of blood coagulation is presented in the form of three phases: initiation, amplification and propagation, each of them includes several consecutive stages. At the same time, thrombus formation is
S.M. Chooklin, S.S. Chuklin
doaj   +1 more source

Shear-induced unfolding and enzymatic cleavage of full-length VWF multimers [PDF]

, 2015
Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within the mechanosensitive A2 domain, which is believed to open under shear flow.
arxiv   +1 more source

Coagulation factors in whole blood collected from pregnant women and stored at 4°C [PDF]

, 2016
2016-02The present study aimed to measure the levels of coagulation factors in stored whole blood of pregnant women and to determine their usefulness in treating pregnant women who developed coagulopathy.
61848, 61849, 61850, 61851, 61852, 61853, 61854, 61855, 61856, 61857, Asada, Rumiko, Ikebuchi, Kenji, Ishihara, Osamu, Itakura, Atsuo, Kajihara, Takeshi, Kobayashi, Kiyoko, Miki, Akinori, Minatoguchi, Miki, Sasaki, Shiho, Takase, Yumiko   +19 more
core  

Successful treatment of refractory gastrointestinal bleeding by systemic (oral) ankaferd blood stopper in a patient with Glanzmann thrombasthenia [PDF]

, 2015
Background: Glanzmann Thrombasthenia (GT) is a genetic platelet dysfunction and a life threatening disease. Ankaferd Blood Stopper (ABS) is a topical hemostatic agent of herbal origin which has been recently made available for clinical use.
Doğu, Mehmet Hilmi, Hacıoğlu, Sibel Kabukçu, Keskin, Ali, Sarı, İsmail   +3 more
core   +2 more sources

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Incorporation of Evidence-based Guidelines on Bleeding Risk Assessment Prior to Surgery into Practice: Real-time Experience

Oman Medical Journal, 2022
Objectives: Despite guidelines recommending no need for coagulation testing before surgeries when a history of bleeding is negative, surgeons still overuse it in this part of the world.
Nada Al-Marhoobi, Manar Maktoom, Mohamed Elshinawy, Hanan Nazir, Khalid Al Hashmi, Rashid Al-Abri, Khalil Macki, Abdulhakim Al-Rawas, Fatma AlBulushi, Yasser Wali, Doaa Khater   +10 more
doaj   +1 more source

Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI.

Blood, 1981
Previous studies have suggested that human platelets can promote the activation of factor XI by two different mechanisms, one requiring factor XII and ADP-treated platelets and the other requiring collagen-treated platelets in the apparent absence of ...
P. Walsh, J. Griffin
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source