Results 91 to 100 of about 2,362,330 (266)

Limited utility of blood cultures in the management of febrile outpatient kidney transplant recipients

Journal of Microbiology, Immunology and Infection, 2017
Background/Purpose: Blood cultures for patients suspected of having bacteremia are standard practice, although several studies demonstrate that blood cultures have limited utility because of a low true-positive rate and infrequent resultant changes in ...
Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate, Naoki kawagishi, Noriaki Ohuchi   +6 more
doaj   +1 more source

The prevalence of bacterial contamination in donated blood in Dar es salaam, Tanzania [PDF]

, 2012
Blood transfusion services are required to provide blood and components which are safe in cost effective way for transfusion into patients who require the blood products.
Malimu, Emmanuel Zephania
core  

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Allen, James M., Baker, Andrew H., Chamberlain, Jeffrey S., Craig, Margaret Anne, Dominiczak, Anna F., Gilday, Kirsten, Graham, Delyth, Gregorevic, Paul, Masson, Rachel, McBride, Martin, Napoli, Claudio, Nicklin, Stuart A., Smith, Godfrey   +12 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Xanthogranulomatous pyelonephritis: presentation and management [PDF]

, 2019
Xanthogranulomatous pyelonephritis (XGP) is characterized by the presence of lipid-laden foamy macrophages with both acute and chronic phase inflammatory cells.
Badiu, Dumitru Cristinel, Constantin, Vlad D., Mareș, Cristian, Mastalier, Bogdan, Mehedințu, Claudia, Măru, Nicoleta, Petca, Aida, Petca, Răzvan C., Popescu, Răzvan I.   +8 more
core   +1 more source

M-DC8+leukocytes - A novel human dendritic cell population [PDF]

, 1999
Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies.
Federle, Christine, Mayer, Elfriede, Poppe, Claudia, Rieber, Ernst Peter, Riethmüller, Gert, Schäkel, Knut   +5 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Assessing the prevalence of antimicrobial resistance among pediatric patients at Kamuzu Central Hospital, Malawi

Journal of Infection in Developing Countries
Introduction: Severe bacterial infections cause significant disease burden in developing countries, including Malawi. The situation is compounded by the scarcity of resources, inconsistent availability of antibiotics, and increasing antimicrobial ...
Agness C Chitedze, Rizine R Mzikamanda, Tarsizio Maida, Casey L McAtee, Lovemore Mapahla, Nicholas Feasey, Peter S Nyasulu   +6 more
doaj   +1 more source

Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift [PDF]

, 2014
<b>Background</b> Understanding of malaria pathogenesis caused by Plasmodium falciparum has been greatly deepened since the introduction of in vitro culture system, but the lack of a method to enrich ring-stage parasites remains a technical ...
Chan, Sherwin, Franke, Thomas, Geislinger, Thomas M, Moll, Kirsten, Wahlgren, Mats, Wixforth, Achim   +5 more
core   +1 more source