Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]
npj Systems Biology and Applications, 10(1), 105 (2024), 2023 As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
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Does blood type affect the COVID-19 infection pattern? [PDF]
PLoS ONE (2021);16(5): e0251535, 2020 Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: (i) the great geographical differences in the degree of virus contagiousness and lethality which were found in the different phases of the epidemic progression, and (ii) the potential role of the infected people's blood type in both the ...
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Histo-blood group glycans in the context of personalized medicine [PDF]
Biochimica et Biophysica Acta 1860 (2016) 1596-1607, 2019 Background: A subset of histo-blood group antigens including ABO and Lewis are oligosaccharide structures which may be conjugated to lipids or proteins. They are known to be important recognition motifs not only in the context of blood transfusions, but also in infection and cancer development.
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A dynamical modeling to study the adaptive immune system and the influence of antibodies in the immune memory [PDF]
CMES, vol 45(1) pp 83-96 (2009), 2017 Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to challenging problems of modern computing (MONROY, SAAB, GODINEZ, 2004). Simulation systems and mathematical modeling are also beginning use to answer more
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Blood ties: ABO is a trans-species polymorphism in primates [PDF]
, 2012 The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date.
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Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings [PDF]
arXiv, 2022 Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR T-cell targets include IL13Ra2, EGFRvIII, HER2, EphA2, GD2, B7-H3, and chlorotoxin.
arxiv
Detecting T-cell receptors involved in immune responses from single repertoire snapshots [PDF]
PLoS Biol 17(6): e3000314 (2019), 2018 Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires (RepSeq) produces huge datasets of T-cell receptor sequences from blood and tissue samples.
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RCMNet: A deep learning model assists CAR-T therapy for leukemia [PDF]
arXiv, 2022 Acute leukemia is a type of blood cancer with a high mortality rate. Current therapeutic methods include bone marrow transplantation, supportive therapy, and chemotherapy. Although a satisfactory remission of the disease can be achieved, the risk of recurrence is still high. Therefore, novel treatments are demanding. Chimeric antigen receptor-T (CAR-T)
arxiv
A semiparametric regression model for paired longitudinal outcomes with application in childhood blood pressure development [PDF]
Annals of Applied Statistics 2012, Vol. 6, No. 4, 1861-1882, 2013 This research examines the simultaneous influences of height and weight on longitudinally measured systolic and diastolic blood pressure in children. Previous studies have shown that both height and weight are positively associated with blood pressure.
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Quantile regression for mixed models with an application to examine blood pressure trends in China [PDF]
Annals of Applied Statistics 2015, Vol. 9, No. 3, 1226-1246, 2015 Cardiometabolic diseases have substantially increased in China in the past 20 years and blood pressure is a primary modifiable risk factor. Using data from the China Health and Nutrition Survey, we examine blood pressure trends in China from 1991 to 2009, with a concentration on age cohorts and urbanicity.
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