Results 11 to 20 of about 173,069 (269)

Stability and utility of flow cytometric platelet activation tests: A modality to bridge the gap between diagnostic demand and supply

open access: yesPlatelets, 2022
Light transmission aggregometry (LTA) is the gold standard for the diagnosis of platelet function disorders (PFDs). The requirement of customized aggregometer, large blood volume, normal platelet count and processing within 4 hours of venipuncture for ...
Rutvi Gautam Dave   +7 more
doaj   +1 more source

Sticky Platelet Syndrome in Patients with Uninduced Venous Thrombosis

open access: yesTurkish Journal of Hematology, 2013
OBJECTIVE: Sticky platelet syndrome (SPS) is a common autosomal dominant inherited platelet disorder. SPS is characterized by platelet hyperreactivity and is associated with arterial and venous thrombosis.
Emre Tekgündüz   +5 more
doaj   +1 more source

A novel likely pathogenic variant in the RUNX1 gene as the cause of congenital thrombocytopenia

open access: yesBalkan Journal of Medical Genetics, 2023
Heterozygous pathogenic and likely pathogenic sequence variants in the RUNX1 (Runt-related Transcription Factor 1) gene are a common genetic cause of decreased platelet count and/or platelet dysfunction and an increased risk of developing myelodysplasia ...
Despotović M   +6 more
doaj   +1 more source

Physico-Biochemical comparative study for Thyroid disorder patients in Ramadi city [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة, 2015
The study aims at determining the impact of thyroid disorders in some blood and biochemical changes to try determine changes in some of the functions of the body as a result of these disorders, whether physiological or biochemical.
Muthana M. Awad, Abbas A. Hamdi
doaj   +1 more source

Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia

open access: yesTzu Chi Medical Journal, 2022
Platelets play an essential role in primary hemostasis through bleeding and thromboembolism. Thus, the diagnosis or evaluation of impaired hereditary, acquired, and drug-related platelet dysfunction has become imperative.
Chih-Lung Shen, Yi-Feng Wu
doaj   +1 more source

Use of microfluidics to assess the platelet-based control of coagulation

open access: yesPlatelets, 2017
This paper provides an overview of the various types of microfluidic devices that are employed to study the complex processes of platelet activation and blood coagulation in whole blood under flow conditions. We elaborate on how these devices are used to
Magdolna Nagy   +2 more
doaj   +1 more source

Prevalence of platelet reactive antibodies in patient′s refractory to platelet transfusions

open access: yesAsian Journal of Transfusion Science, 2014
Introduction & Aims: Though platelet transfusions have greatly reduced the incidence of major haemorrhagic complications associated with the management of haematological and oncological disorders, refractoriness to infused platelets becomes a major ...
Nitin Agarwal   +3 more
doaj   +1 more source

Evaluating hemostatic thresholds for neuraxial anesthesia in adults with hemorrhagic disorders and tendencies: A scoping review

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2021
Neuraxial anesthesia can be complicated by spinal or epidural hematoma and may result in permanent neurologic injury. There is a paucity of literature characterizing this serious complication in patients with congenital and acquired hemorrhagic disorders
Wynn Peterson   +4 more
doaj   +1 more source

Diagnosis of inherited platelet disorders on a blood smear: a tool to facilitate worldwide diagnosis of platelet disorders [PDF]

open access: yesJournal of Thrombosis and Haemostasis, 2017
Essentials There are many hereditary platelet disorders (HPD) but diagnosing these is challenging. We provide a method to diagnose several HPDs using standard blood smears requiring < 100 µL blood. By this approach, the underlying cause of HPD was characterized in ~25-30% of referred individuals.
Greinacher, Andreas   +6 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

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