Results 21 to 30 of about 296,969 (239)

Rupture Forces among Human Blood Platelets at different Degrees of Activation [PDF]

, 2020
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states.
arxiv   +1 more source

Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography

Platelets, 2018
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot, Clémence Docq, Denis Wahl, Patrick Lacolley, Véronique Regnault, Jérémy Lagrange   +5 more
doaj   +1 more source

A novel likely pathogenic variant in the RUNX1 gene as the cause of congenital thrombocytopenia

Balkan Journal of Medical Genetics, 2023
Heterozygous pathogenic and likely pathogenic sequence variants in the RUNX1 (Runt-related Transcription Factor 1) gene are a common genetic cause of decreased platelet count and/or platelet dysfunction and an increased risk of developing myelodysplasia ...
Despotović M, Pereza N, Peterlin B, Ostojić S, Golob B, Maver A, Roganović J   +6 more
doaj   +1 more source

Sticky Platelet Syndrome in Patients with Uninduced Venous Thrombosis

Turkish Journal of Hematology, 2013
OBJECTIVE: Sticky platelet syndrome (SPS) is a common autosomal dominant inherited platelet disorder. SPS is characterized by platelet hyperreactivity and is associated with arterial and venous thrombosis.
Emre Tekgündüz, Muzaffer Demir, Seval Akpınar, Alev Akyol Erikçi, Erman Öztürk, Onur Kırkızlar   +5 more
doaj   +1 more source

Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia

Tzu Chi Medical Journal, 2022
Platelets play an essential role in primary hemostasis through bleeding and thromboembolism. Thus, the diagnosis or evaluation of impaired hereditary, acquired, and drug-related platelet dysfunction has become imperative.
Chih-Lung Shen, Yi-Feng Wu
doaj   +1 more source

Evaluating hemostatic thresholds for neuraxial anesthesia in adults with hemorrhagic disorders and tendencies: A scoping review

Research and Practice in Thrombosis and Haemostasis, 2021
Neuraxial anesthesia can be complicated by spinal or epidural hematoma and may result in permanent neurologic injury. There is a paucity of literature characterizing this serious complication in patients with congenital and acquired hemorrhagic disorders
Wynn Peterson, Brandon Tse, Rachel Martin, Michael Fralick, Michelle Sholzberg   +4 more
doaj   +1 more source

AI-aided multiscale modeling of physiologically-significant blood clots [PDF]

, 2022
We have developed an AI-aided multiple time stepping (AI-MTS) algorithm and multiscale modeling framework (AI-MSM) and implemented them on the Summit-like supercomputer, AIMOS. AI-MSM is the first of its kind to integrate multi-physics, including intra-platelet, inter-platelet, and fluid-platelet interactions, into one system. It has simulated a record-
arxiv   +1 more source

Physico-Biochemical comparative study for Thyroid disorder patients in Ramadi city [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2015
The study aims at determining the impact of thyroid disorders in some blood and biochemical changes to try determine changes in some of the functions of the body as a result of these disorders, whether physiological or biochemical.
Muthana M. Awad, Abbas A. Hamdi
doaj   +1 more source

Repeated successful use of eltrombopag in chronic primary immune thrombocytopenia: description of an intriguing case. [PDF]

, 2017
Thrombopoietin receptor agonists (TPO-RAs) are used as effective alternative treatments in ITP patients unresponsive to first-/second-line therapies.
Baldacci, Erminia, DI ROCCO, Alice, Ferrara, Grazia, Ferretti, Antonietta, Mazzucconi, Maria Gabriella, Porrazzo, Marika, Santoro, Cristina, Volpicelli, Paola   +7 more
core   +1 more source

A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis [PDF]

, 2018
A key role of both coagulation and vascular thrombosis has been reported since the first descriptions of multiple sclerosis (MS). Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of ...
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core   +1 more source