Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong +21 more
wiley +1 more source
Vascular surveillance by haptotactic blood platelets in inflammation and infection. [PDF]
Nicolai L +30 more
europepmc +1 more source
Transfusion of Blood Products in Trauma Victims: Effects of Fresh Frozen Plasma, Platelet and Intravenous Fluid to Packed Red Blood Cell Volume Ratios on Survival [PDF]
Michael C. Plewa +5 more
openalex +1 more source
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source
Tumor-mediated remote regulation of peripheral blood platelets. [PDF]
Wu R +11 more
europepmc +1 more source
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen +11 more
wiley +1 more source
Estimated Amounts of β-Carotene, Vitamin B6, Riboflavin and Niacin in the Daily Diet of Older Subjects Associate Negatively with ADP-Induced Aggregation of Blood Platelets Independently of Cardiovascular Risk Factors. [PDF]
Karolczak K +5 more
europepmc +1 more source
Three Milliliters of Peripheral Blood Is Sufficient for Preparing Liquid Platelet-Rich Fibrin (PRF): An In Vitro Study [PDF]
Sarah Al‐Maawi +3 more
openalex +1 more source

