Results 41 to 50 of about 4,620,115 (383)

EDTA stabilizes the concentration of platelet-derived extracellular vesicles during blood collection and handling

open access: yesPlatelets, 2022
Citrate is the recommended anticoagulant for studies on plasma extracellular vesicles (EVs). Because citrate incompletely blocks platelet activation and the release of platelet-derived EVs, we compared EDTA and citrate in that regard.
Naomi C. Buntsma   +5 more
doaj   +1 more source

Quantitative structural mechanobiology of platelet-driven blood clot contraction. [PDF]

open access: yes, 2017
Blood clot contraction plays an important role in prevention of bleeding and in thrombotic disorders. Here, we unveil and quantify the structural mechanisms of clot contraction at the level of single platelets.
Alber, Mark S   +3 more
core   +2 more sources

Rupture Forces among Human Blood Platelets at different Degrees of Activation [PDF]

open access: yes, 2020
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the adhesion forces of single platelet-platelet interaction at different activation states.
arxiv   +1 more source

Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets [PDF]

open access: yes, 2003
Although tissue factor (TF), the principial initiator of physiological coagulation and pathological thrombosis, has recently been proposed to be present in human blood, the functional significance and location of the intravascular TF is unknown.
Alex, Meike   +9 more
core   +1 more source

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.

open access: yesJournal of the American Medical Association (JAMA), 2015
IMPORTANCE Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation, has been ...
J. Holcomb   +31 more
semanticscholar   +1 more source

Dose-dependent effect of canine lyophilized platelet on an in vitro hemodilution model

open access: yesBMC Veterinary Research, 2023
The transfusion of stored platelets has emerged as an efficient method for treating dogs with thrombocytopenia. However, the availability of fresh platelets is limited in veterinary medicine due to demanding storage conditions. Lyophilized platelets have
Mu-Young Kim, Hyun-Jung Han
doaj   +1 more source

The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents [PDF]

open access: yes, 2005
Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease.
Campetella, O.   +4 more
core   +2 more sources

Topographic Cues Reveal Two Distinct Spreading Mechanisms in Blood Platelets

open access: yesScientific Reports, 2016
Blood platelets are instrumental in blood clotting and are thus heavily involved in early wound closure. After adhering to a substrate they spread by forming protrusions like lamellipodia and filopodia.
R. Sandmann, S. Köster
semanticscholar   +1 more source

Role of Thrombocytic-Vascular Hemostasis in the Development of Pulmonary Complications in Severe Brain Injury

open access: yesОбщая реаниматология, 2006
The purpose of the study was to define a role of thrombocytic-vascular hemostasis in the development of pulmonary complications in severe brain injury. Forty-six patients with severe brain injury were studied over time.
Yu. A. Churlyaev, L. Yu. Redkokasha
doaj   +1 more source

Intraoperative blood transfusions in highly alloimmunized patients undergoing orthotopic liver transplantation. [PDF]

open access: yes, 1989
Intraoperative blood requirements were analyzed in patients undergoing primary orthotopic liver transplantation and divided into two groups on the basis of panel reactive antibody of pretransplant serum measured by lymphocytotoxicity testing.
Duquesnoy, RJ   +5 more
core   +1 more source

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