Results 71 to 80 of about 4,705,585 (363)

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of subjects infected ...
Y. Zaid, F. Puhm, I. Allaeys, A. Naya, M. Oudghiri, L. Khalki, Y. Limami, N. Zaid, K. Sadki, R. Ben El Haj, W. Mahir, L. Belayachi, B. Belefquih, A. Benouda, A. Cheikh, Marc-André Langlois, Y. Cherrah, L. Flamand, F. Guessous, É. Boilard   +19 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

THE ELECTROPHORESIS OF THE BLOOD PLATELETS OF THE HORSE WITH REFERENCE TO THEIR ORIGIN AND TO THROMBUS FORMATION

Journal of Experimental Medicine, 1928
1. The cataphoretic velocity of blood platelets (horse) in plasma has been found to be between 40 and 51 µ per sec. per volt per cm. The mean velocity obtained from five horses is . 45 µ per sec. per volt per cm. 2.
H. Abramson
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Design of the Randomized Controlled Trial Comparing Dimethyl Sulfoxide Cryopreserved Platelets to Liquid Stored Platelets in Patients Undergoing Cardiopulmonary Bypass SurgeryCentral MessagePerspective

JTCVS Open, 2023
Objective: Dimethylsulfoxide-cryopreserved platelets are being evaluated for treatment of acute hemorrhage in patients with thrombocytopenia or platelet dysfunction when liquid stored platelets are unavailable.
Glenn Whitman, MD, Robert Kramer, MD, Kenichi Tanaka, MD, John Holcomb, MD, G. Michael Fitzpatrick, PhD, Jacob Raphael, MD, Paul Ness, MD   +6 more
doaj  

Platelets in Amyloidogenic Mice Are Activated and Invade the Brain

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD) is a neurodegenerative disease with a complex and not fully understood pathogenesis. Besides brain-intrinsic hallmarks such as abnormal deposition of harmful proteins, i.e., amyloid beta in plaques and hyperphosphorylated Tau in ...
Kathrin M. Kniewallner, Kathrin M. Kniewallner, Diana M. Bessa de Sousa, Diana M. Bessa de Sousa, Michael S. Unger, Michael S. Unger, Heike Mrowetz, Heike Mrowetz, Ludwig Aigner, Ludwig Aigner, Ludwig Aigner   +10 more
doaj   +1 more source

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

BLOOD PLATELETS AS ACTIVATORS AND REGULATORS OF INFLAMMATORY AND IMMUNE REACTIONS. PART 1. BASIC CHARACTERISTICS OF PLATELETS AS INFLAMMATORY CELLS

Медицинская иммунология, 2018
Platelets are the smallest blood cells, and yet their total volume and surface area exceed those of all types of leukocytes combined. Platelets are produced by the bone marrow megakaryocytes and megakaryocytes in the lung microvessels.
N. B. Serebryanaya, S. N. Shanin, E. E. Fomicheva, P. P. Yakutseni   +3 more
doaj   +1 more source

Origin of Blood Platelets [PDF]

Nature, 1955
THE conclusion of J. H. Wright1 that blood platelets are detached portions of the cytoplasm of megakaryocytes has been supported by much circumstantial evidence, and is generally accepted2, although unequivocal direct evidence is lacking.
openaire   +3 more sources