Results 81 to 90 of about 477,959 (352)
Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. [PDF]
PLoS ONE, 2009 BACKGROUND:Aggregates formed between leukocytes and platelets in the circulation lead to release of tissue factor (TF)-bearing microparticles contributing to a prothrombotic state.
Anne-lie Ståhl +4 more
doaj +1 more source
Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. [PDF]
, 1978 The effect of the common lipid moiety of bacterial LPS on secretion from washed human platelets has been studied. The lipid A-rich LPS of S. minnesota R595 and a lipid A preparation both potentiated platelet serotonin secretion in response to IgG ...
Ginsberg, MH, Henson, PM
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang +16 more
wiley +1 more source
In vitro-derived platelets: the challenges we will have to face to assess quality and safety
Platelets, 2020 Platelet transfusions are given to patients in hospital who have a low blood platelet count (thrombocytopenia) either because of major bleeding (following trauma or surgery) or because the bone marrow production of platelets is impaired often due to ...
S. Mookerjee +3 more
doaj +1 more source
The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization
Advanced Biology, EarlyView.This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates +7 more
wiley +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
Erythrocytes morphology and hemorheology in severe bacterial infection [PDF]
Memorias do Instituto Oswaldo Cruz, 2019 BACKGROUND Severe bacterial infections initiate inadequate inflammation that leads to disseminated intravascular coagulation and death. OBJECTIVES To evaluate the influence of bacterial infection on blood viscosity and red blood cells (RBCs ...
Ayrles FB Silva +7 more
doaj +1 more source
THE RATE OF REGENERATION OF BLOOD PLATELETS [PDF]
Journal of Experimental Medicine, 1911 By repeatedly withdrawing, defibrinating, and reinjecting blood, the platelet count in dogs can be reduced to an extremely low level. When the reduction in platelets and fibrinogen has been carried to an extreme degree the animals display a marked tendency to bleed.
openaire +5 more sources
A Process-Oriented Architecture for Complex System Modelling [PDF]
, 2007 A fine-grained massively-parallel process-oriented model of platelets (potentially artificial) within a blood vessel is presented. This is a CSP inspired design, expressed and implemented using the occam-pi language. It is part of the TUNA pilot study on
Ritson, Carl G., Welch, Peter H.
core
Advanced Biology, EarlyView.In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins +2 more
wiley +1 more source