Results 81 to 90 of about 4,844,363 (388)

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

open access: yesAdvanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates   +7 more
wiley   +1 more source

Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: Pro-coagulant membrane microvesicles (MV) derived from platelets and leukocytes are shed into the circulation following receptor-mediated activation, cell-cell interaction, and apoptosis. Platelets are sentinel markers of toll-like receptor 4
Jing Xiong   +4 more
doaj   +1 more source

Platelet CD40L Expression Response to Mixing of pRBCs and Washed Platelets but no Causality Association between Platelet ROS Generation and CD40L Expression: An In Vitro Study

open access: yesAntioxidants, 2022
Platelets play a role in transfusion reaction via reactive oxygen species (ROS) generation and CD40 ligand (CD40L) expression. In this study, we aimed to test the hypothesis that the mixing of packed red blood cells (pRBCs) and washed platelets has a ...
Mei-Hua Hu   +3 more
doaj   +1 more source

Precise Quantification of Angiogenesis in 3D Biomaterials Using in Vitro CAM Models: Enhancing 3Rs in Research and Minimizing in Vivo Dependency

open access: yesAdvanced Functional Materials, EarlyView.
The study develops elastin–fibrin scaffolds and evaluates angiogenesis using the chorioallantoic membrane (CAM) model. Advanced imaging with confocal microscopy and Indocyanine Green dye enables precise 3D quantification of vascular networks. Findings demonstrate superior microvessel visualization compared to micro‐CT using Microfil and Optiray 350 ...
Ece Melis Er   +8 more
wiley   +1 more source

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season [PDF]

open access: yes, 2010
Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood.
Breitner, Susanne   +8 more
core   +1 more source

Platelet Function in Platelet Concentrates and in Whole Blood [PDF]

open access: yesAnaesthesia and Intensive Care, 1985
Platelet function was studied in CPD whole blood stored at 4°C for one and three days and in platelet concentrates stored at room temperature for the same periods of time. Comparisons were made of platelet shape, nucleotide content, β-thromboglobulin (βTG) liberated during storage, and platelet aggregation in response to ADP, collagen, sodium ...
S E, Rodgers, J V, Lloyd, W J, Russell
openaire   +2 more sources

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang   +9 more
wiley   +1 more source

PLATELET TURNOVER AND ATHEROTHROMBOSIS

open access: yesАтеротромбоз, 2017
Platelets play an important role in initiating atherothrombosis, i.e. the formation of blood clots inside a blood vessel at areas of atherosclerotic vascular injury.
A. V. MAZUROV
doaj   +1 more source

Therapeutic use of red blood cells and platelets derived from human cord blood stem cells

open access: yesStem Cells Translational Medicine, 2021
Red blood cells (RBCs) and platelets derived from stem cells are possible solutions to the increasing demand for blood transfusion. Based on the availability of stem cells, their relatively defined differentiation mechanisms, and the massive exploration ...
Xiaoyan Xie   +4 more
doaj   +1 more source

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