Results 271 to 280 of about 1,516,611 (334)

Erratum: Bellocchio et al., "Sustained G_q-Protein Signaling Disrupts Striatal Circuits via JNK". [PDF]

J Neurosci
europepmc   +1 more source

Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosis. [PDF]

EBioMedicine
Ji ML, Wang JN, Wu MF, Xu CH, Zhang MM, Chang WB, Mao XF, Li C, Yu JT, Zhang DF, Suo XG, Diao SX, Ma NN, Chen Y, Hou R, Lu H, Xie SS, Dong YH, Zhu Q, Chen X, Xu T, Shao W, Jin J, Wen JG, Dong XW, Wang WB, Che JX, Meng XM.   +27 more
europepmc   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Toxoplasma GRA16 attenuates Tau hyperphosphorylation and enhances autophagy in thrombin-treated HT-22 hippocampal neuronal cells. [PDF]

Sci Rep
Seo SH, Ham DW, Lee JE, Shin EH.
europepmc   +1 more source

Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation

Advanced Materials, EarlyView.
Dynamic nanoscale groove‐ridge structures are engineered by flexibly conjugating RGD‐magnetic nanoparticles to nanogroove templates with variable groove widths at the molecular scale. Magnetic control enables cyclic switching between nanoscale groove and ridge states that modulates ligand accessibility of cellular integrins.
Hyunsik Hong, Dahee Kim, Hwapyung Jung, Seongyeol Kim, Sunhong Min, Chowon Kim, Kanghyeon Kim, Hyunji Rha, Heemin Kang   +8 more
wiley   +1 more source

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Mesenchymal stem cells enhance selective ER-phagy to promote α-synuclein clearance in Parkinson's disease. [PDF]

Stem Cells Transl Med
Lee JE, Oh KW, Shin JY, Kim YJ, Lee SJ, Lee PH.   +5 more
europepmc   +1 more source

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

Advanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar, David S. Lee, Daniel Cabrerizo‐Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela‐Velasco, Analisa Murray, Stacey Gerben, Anindya Roy, Cole A. DeForest, Timothy Springer, Hannele Ruohola‐Baker, Jonathan A. Cooper, Melody G. Campbell, Jose Maria Manero, Maria‐Pau Ginebra, David Baker   +25 more
wiley   +1 more source

METTL3 mediated m6A modification of HKDC1 promotes renal injury and inflammation in lead nephropathy. [PDF]

Int J Biol Sci
Suo XG, Wang JN, Zhu Q, Zhang MM, Ge QL, Peng LJ, Wang YY, Ji ML, Ou YM, Yu JT, Lu H, Cheng XR, Hou BB, Chen X, Zhu S, Li XY, Li C, Xie SS, Yang C, Li FH, Jin J, Wang F, Meng XM.   +22 more
europepmc   +1 more source