Results 61 to 70 of about 1,441,912 (353)
Microfluidic Western blotting [PDF]
Proceedings of the National Academy of Sciences, 2012 Rapid, quantitative Western blotting is a long-sought bioanalytical goal in the life sciences. To this end, we describe a Western blotting assay conducted in a single glass microchannel under purely electronic control. The μWestern blot is comprised of multiple steps: sample enrichment, protein sizing, protein immobilization (blotting), and in situ ...
Alex J, Hughes, Amy E, Herr
openaire +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Le tumulus Irau 4: compte rendu de fouilles 1988 (autorisation nº 88/14). [PDF]
Munibe Antropologia-Arkeologia, 1989 Este túmulo, excavado en 1988, mide 5,5 m. de diámetro y 0,50 m. de alto. Es un amontonamiento de bloques de piedra sin ningún orden. En el centro una pequeña cista, configurada por 12 losas incadas, delimita un espacio cerrado, irregular, de 0,60 m. x 0,
Jacques Blot
doaj
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Le Cromlech Méatsé 12 (commune d'Itxassou, Laburdi). (Compte rendu de fouilles 1994). [PDF]
Munibe Antropologia-Arkeologia, 1996 El cromlech Meatsé 12, de 5 m. de diámetro, presenta una corona periférica constituída por pequeños amontonamientos de losetas superpuestas, que rodean por el exterior a una serie de grandes losas dispuestas tangencialmente en círculo.
Jacques Blot
doaj
Dot blot immunochemical and infrared analyses of the adhesive layer applied to the painting Imago Pietatis by Domenico Morone [PDF]
, 2022 Cristina Cattò +4 more
openalex +1 more source
Southwestern Blotting Assay [PDF]
, 2015 Southwestern blotting is a technique used to study DNA-protein interactions. This method detects specific DNA-binding proteins by incubating radiolabeled DNA with a gel blot, washing, and visualizing through autoradiography. A blot resulting from 1-dimensional SDS-PAGE reveals the molecular weight of the binding proteins.
Yinshan, Jia +2 more
openaire +2 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Bio-Protocol, 2015 Ultraviolet (UV) irradiation induces helix distorting photolesions such as cyclobutane pyrimidine dimers (CPD) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PP) which threaten genomic integrity if unrepaired.
Jeong-Min Park, Tae-Hong Kang
doaj +1 more source