Results 61 to 70 of about 1,558,933 (353)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Les cromlechs d'Apatesaro I et I bis (Compte rendu de fouilles). [PDF]
Munibe Antropologia-Arkeologia, 1984 Se da cuenta de los resultados obtenidos en la excavación de los cromlechs de Apatesaro, datados en el primer milenio a.C.
Jacques Blot
doaj
LE PLAN HYDROLOGIQUE NATIONAL, CONTINUITE D'UNE POLITIQUE DE L'EAU POUR L'ESPAGNE [PDF]
, 2003 International audienceL'Espagne a adopté en juillet 2001 un Plan Hydrologique National (PHN) que le gouvernement central veut significatif d'une « nouvelle politique de l'eau solidaire », en rupture avec le modèle traditionnel de planification ...
Blot, Frédérique
core +1 more source
Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]
, 2017 Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh +16 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Le tumulus Irau 4: compte rendu de fouilles 1988 (autorisation nº 88/14). [PDF]
Munibe Antropologia-Arkeologia, 1989 Este túmulo, excavado en 1988, mide 5,5 m. de diámetro y 0,50 m. de alto. Es un amontonamiento de bloques de piedra sin ningún orden. En el centro una pequeña cista, configurada por 12 losas incadas, delimita un espacio cerrado, irregular, de 0,60 m. x 0,
Jacques Blot
doaj
On the Almost Everywhere Continuity
, 2014 The aim of this paper is to provide characterizations of the Lebesgue-almost everywhere continuity of a function f : [a, b] $\rightarrow$ R. These characterizations permit to obtain necessary and sufficient conditions for the Riemann integrability of f
Blot, Joël
core +1 more source
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]
, 2016 The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J. +3 more
core +1 more source
Southwestern Blotting Assay [PDF]
, 2015 Southwestern blotting is a technique used to study DNA-protein interactions. This method detects specific DNA-binding proteins by incubating radiolabeled DNA with a gel blot, washing, and visualizing through autoradiography. A blot resulting from 1-dimensional SDS-PAGE reveals the molecular weight of the binding proteins.
Yinshan, Jia +2 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source