Results 81 to 90 of about 272,370 (331)
Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Bone morphogenetic proteins (BMPs) are essential signaling molecules important in embryo development and maintaining tissue function in adulthood. BMPs are regulated outside the cell by inhibitors such as chordin. The structure of chordin is unknown as extracellular proteins are generally not suitable for high-resolution methods.
Troilo, Helen +8 more
openaire +4 more sources
BMP signaling and its paradoxical effects in tumorigenesis and dissemination
OncoTarget, 2016 Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal development by regulating cell differentiation, proliferation, motility, and survival, thus maintaining homeostasis during organ and tissue development.
Lijie Zhang +5 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash +4 more
wiley +1 more source
The formative evaluation of a forestry Best Management Practices program in a municipal watershed
The Forestry Chronicle, 2020 Best Management Practices for water quality (BMPs) have been proven effective in reducing sedimentation from timber harvesting operations. Although most states in the country have BMP guidelines, many are non-regulatory, creating challenges for forest ...
Emily Paye +2 more
doaj +1 more source
Biology, 2023 Bone formation is driven by many signaling molecules including bone morphogenetic protein 9 (BMP-9) and hypoxia-inducible factor 1-alpha (HIF-1α). We demonstrated that cell therapy using mesenchymal stem cells (MSCs) overexpressing BMP-9 (MSCs+BMP-9 ...
Jessica Emanuella Rocha Moura Paz +8 more
doaj +1 more source
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]
, 2016 Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core +1 more source
Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
Nature Communications, 2016 Functional blood vessel growth depends on generation of distinct but coordinated responses from endothelial cells. Bone morphogenetic proteins (BMP), part of the TGFβ superfamily, bind receptors to induce phosphorylation and nuclear translocation of SMAD
K. Mouillesseaux +14 more
semanticscholar +1 more source
A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering
Advanced Healthcare Materials, EarlyView.In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng +8 more
wiley +1 more source
Arthritis Research & Therapy, 2020 Background Excessive bone formation in the entheses is one of the features of peripheral spondyloarthritis (SpA). Complex pathological mechanisms connecting inflammation, mechanical stress, and ossification are probably involved.
Anne Briolay +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen +9 more
wiley +1 more source