Results 141 to 150 of about 52,292 (275)

Advances in the genetics of refractive errors: Contributions from the CREAM consortium

Acta Ophthalmologica, EarlyView.
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li, Xi He, Louise Terry, Virginie J. M. Verhoeven, Samantha Sze‐Yee Lee, Gareth Lingham, Jeremy A. Guggenheim, David A. Mackey, Seang‐Mei Saw, Caroline C. W. Klaver, Chi Pui Pang, CREAM Consortium   +11 more
wiley   +1 more source

Axial length, myopia progression, and myopic maculopathy in Stickler syndrome

Acta Ophthalmologica, EarlyView.
Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen, Mette Bertelsen, Nanna D. Rendtorff, Stense Farholt, Line Kessel   +4 more
wiley   +1 more source

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression [PDF]

, 2009
Hemojuvelin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins (BMPs) and neogenin. Cellular HJV acts as a BMP co-receptor to enhance the transcription of hepcidin, a key iron regulatory hormone secreted ...
An-Sheng Zhang, Andriopoulos, Babitt, Babitt, Babitt, Camaschella, Caroline A. Enns, Conrad, Davies, De Domenico, De Gobbi, Du, Fan Yang, Feng, Feng, Finberg, Frazer, Goldschneider, Hentze, Hidekazu Tsukamoto, Huang, Jiaohong Wang, Kautz, Kuns-Hashimoto, Lin, Lin, Luxon, Matsunaga, Matsunaga, Maxson, Meynard, Niederkofler, Papanikolaou, Pigeon, Samad, Schaffar, Silvestri, Wang, Xia, Xia, Yang, Zhang, Zhang, Zhang, Zhang   +44 more
core   +4 more sources

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, EarlyView.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells [PDF]

, 2004
Neural crest stem cells (NCSCs) persist in peripheral nerves throughout late gestation but their function is unknown. Current models of nerve development only consider the generation of Schwann cells from neural crest, but the presence of NCSCs raises ...
Anderson, David J., Crone, Steven A., Dormand, Emma-Louise, Jaegle, Martine, Joseph, Nancy M., Lee, Kuo-Fen, Meijer, Dies, Morrison, Sean J., Mosher, Jack T., Mukouyama, Yoh-suke   +9 more
core   +1 more source

BMP4 supports noradrenergic differentiation by a PKA-dependent mechanism

Developmental Biology, 2005
Differentiation of neural crest-derived noradrenergic neurons depends upon signaling mediated downstream of BMP binding to cognate receptors and involving cAMP. Compiled data from many groups suggest that neurogenesis and cell type-specific noradrenergic marker gene regulation is coordinated through the expression and function of the basic helix-loop ...
Liu, Hongbin, Margiotta, Joseph F., Howard, Marthe J.   +2 more
openaire   +2 more sources

A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models

Cancer Science, EarlyView.
We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa, Daisuke Komura, Takayuki Isagawa, Yusuke Amano, Atsushi Kihara, Tamaki Miura, Taichiro Yoshimoto, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Tetsuo Ushiku, Shumpei Ishikawa, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki   +16 more
wiley   +1 more source

Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro

Scientific Reports, 2017
SGNs are the primary auditory neurons, and damage or loss of SGNs leads to sensorineural hearing loss. BMP4 is a growth factor that belongs to the TGF-β superfamily and has been shown to play a key role during development, but little is known about its ...
Muhammad Waqas, Shan Sun, Chuanyin Xuan, Qiaojun Fang, Xiaoli Zhang, Irum-us Islam, Jieyu Qi, Shasha Zhang, Xia Gao, Mingliang Tang, Haibo Shi, Huawei Li, Renjie Chai   +12 more
doaj   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

Clinical Genetics, EarlyView.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li, Xin Hou, Xiangyu Wang, Juan Li, Li Li, Xiangyi Ma   +5 more
wiley   +1 more source

Genetische Ursachen von Neuralrohrdefekten beim Menschen - Assoziationsstudien und Kandidatengenanalysen [PDF]

, 2003
Neuralrohrdefekte (NRD) sind häufig auftretende angeborene Fehlbildungen des Zentralen Nervensystems, über deren Ursachen bis heute nur wenig bekannt ist.
Felder, Bärbel, Felder, Bärbel
core   +1 more source