Results 51 to 60 of about 905,740 (294)

Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo.

PLoS Genetics, 2016
The BMP signaling pathway has a conserved role in dorsal-ventral axis patterning during embryonic development. In Drosophila, graded BMP signaling is transduced by the Mad transcription factor and opposed by the Brinker repressor.
Lisa Deignan, Marco T Pinheiro, Catherine Sutcliffe, Abbie Saunders, Scott G Wilcockson, Leo A H Zeef, Ian J Donaldson, Hilary L Ashe   +7 more
doaj   +1 more source

Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool

Stem Cell Reports, 2018
Summary: In developing organisms, proper tuning of the number of stem cells within a niche is critical for the maintenance of adult tissues; however, the involved mechanisms remain largely unclear.
Chen-Yuan Tseng, Yu-Han Su, Shun-Min Yang, Kun-Yang Lin, Chun-Ming Lai, Elham Rastegari, Oyundari Amartuvshin, Yueh Cho, Yu Cai, Hwei-Jan Hsu   +9 more
doaj   +1 more source

Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model

Bone Research, 2022
Spondylocarpotarsal syndrome (SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions resulting from biallelic nonsense mutations in the gene encoding filamin B (FLNB).
Jennifer Zieba, Kimberly N. Forlenza, Kelly Heard, Jorge H. Martin, Michaela Bosakova, Daniel H. Cohn, Stephen P. Robertson, Pavel Krejci, Deborah Krakow   +8 more
doaj   +1 more source

Pentagone: patrolling BMP morphogen signaling [PDF]

Fly, 2011
Orchestration of spatial organization by signaling gradients--morphogen gradients--is a fundamental principle in animal development. Despite their importance in tissue patterning and growth, the exact mechanisms underlying the establishment and maintenance of morphogen gradients are poorly understood. Our recent work on BMP (bone morphogenetic protein)
Vuilleumier, Robin, Affolter, Markus, Pyrowolakis, George   +2 more
openaire   +3 more sources

TAK1 mediates BMP signaling in cartilage [PDF]

Annals of the New York Academy of Sciences, 2010
Although many signals are capable of activating MAPK signaling cascades in chondrocytes in vitro, the function of these pathways remains unclear in vivo. Here we report the phenotype of mice with a conditional deletion of TGF‐β‐activated kinase 1 (TAK1), a MAP3K family member, in cartilage using the collagen 2α promoter.
Matthew B, Greenblatt, Jae-Hyuck, Shim, Laurie H, Glimcher   +2 more
openaire   +2 more sources

Structural perspective of BMP ligands and signaling [PDF]

Bone, 2020
The Bone Morphogenetic Proteins (BMPs) are the largest class signaling molecules within the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a wide array of biological functions, including dorsal-ventral patterning, skeletal development and maintenance, as well as cell homeostasis. As such, dysregulation of BMPs results in
Gregory R, Gipson, Erich J, Goebel, Kaitlin N, Hart, Emily C, Kappes, Chandramohan, Kattamuri, Jason C, McCoy, Thomas B, Thompson   +6 more
openaire   +2 more sources

Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2

Molecular Therapy: Methods & Clinical Development, 2023
Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclinical
Aysegul Atasoy-Zeybek, Michael J. Coenen, Gresin P. Hawse, Delphine Logeart-Avramoglou, Christopher H. Evans, Rodolfo E. De La Vega   +5 more
doaj   +1 more source

Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish [PDF]

, 2011
The extracellular matrix is crucial for organogenesis. It is a complex and dynamic component that regulates cell behavior by modulating the activity, bioavailability and presentation of growth factors to cell surface receptors.
Novoyatleva, Tatyana, Felix B. Engel, Schäfer, Liliana, Chinmoy Patra, Mühlfeld, Christian, Liliana Schaefer, Christian Mühlfeld, Ferrazzi, Fulvia, Jungblut, Benno, Diehl, Florian, Fulvia Ferrazzi, Florian Diehl, Engel, Felix B., Machteld J. van Amerongen, Amerongen, Machteld J. van, Patra, Chinmoy, Tatyana Novoyatleva, Benno Jungblut   +17 more
core   +1 more source

Tukushi modulates Xnr2, FGF, and and BMP signalling: Regulation of Xenopus Germ Layer Formation [PDF]

, 2007
BACKGROUND: Cell-cell communication is essential in tissue patterning. In early amphibian development, mesoderm is formed in the blastula-stage embryo through inductive interactions in which vegetal cells act on overlying equatorial cells. Members of the
Ohta, K, Ohnuma, S, Tanaka, H, Morris, SA, Almeida, AD   +4 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source