Results 51 to 60 of about 115,318 (308)
A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone
Bone Research, 2020 Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting in degradation of signaling ...
Junichi Kushioka +15 more
doaj +1 more source
Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis [PDF]
, 2015 The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage.
Blinka, Steven +8 more
core +4 more sources
Molecular Therapy: Methods & Clinical Development, 2023 Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclinical
Aysegul Atasoy-Zeybek +5 more
doaj +1 more source
Разработка информационной системы планирования энергоресурсов производственного предприятия OOO "Завод ТехноНИКОЛЬ-Сибирь" [PDF]
, 2012 OBJECTIVE: The expression of bone morphogenetic proteins (BMPs) is enhanced in human atherosclerotic and calcific vascular lesions. While genetic gain- and loss-of-function experiments in mice have supported a causal role of BMP signaling in ...
Aikawa, Elena +8 more
core +1 more source
TGFβ/BMP Signaling Pathway in Cartilage Homeostasis [PDF]
Cells, 2019 Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by growth factors such as those of the transforming growth factor β (TGFβ) family.
Nathalie Thielen +2 more
openaire +5 more sources
BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
Frontiers in Cell and Developmental Biology, 2021 One of the most significant events during early embryonic development is the establishment of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and left-right axes.
Yifang Yan +5 more
doaj +1 more source
The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling [PDF]
Nature, 2000 Dorsal-ventral patterning in vertebrate and Drosophila embryos requires a conserved system of extracellular proteins to generate a positional information gradient. The components involved include bone morphogenetic proteins (BMP/Dpp), a BMP antagonist (Chordin/Short gastrulation; Chd/Sog) and a secreted metalloproteinase (Xolloid/Tolloid) that cleaves ...
M, Oelgeschläger +3 more
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice.
PLoS ONE, 2009 Exposure to exercise or to environmental enrichment increases the generation of new neurons in the adult hippocampus and promotes certain kinds of learning and memory.
Kevin T Gobeske +6 more
doaj +1 more source
BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin
Cell Reports, 2020 Summary: Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning.
Rita Mateus +6 more
doaj +1 more source