Frontiers in Physiology, 2022 Bone morphogenetic protein (BMP) signaling plays essential roles in the regulation of early tooth development. It is well acknowledged that extracellular BMP ligands bind to the type I and type II transmembrane serine/threonine kinase receptor complexes ...
Xiaoxiao Hu +5 more
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Role of miR-17 family in the negative feedback loop of bone morphogenetic protein signaling in neuron. [PDF]
PLoS ONE, 2013 Bone morphogenetic protein (BMP) signaling is active in many tissues including the central nervous system, in which it regulates cell proliferation, differentiation and maturation.
Qi Sun +5 more
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Molecular Brain, 2017 In Drosophila, precise regulation of BMP signaling is essential for normal synaptic growth at the larval neuromuscular junction (NMJ) and neuronal survival in the adult brain.
Keunjung Heo +6 more
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Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints
Cell Reports, 2015 BMP signaling plays a crucial role in the establishment of the dorso-ventral body axis in bilaterally symmetric animals. However, the topologies of the bone morphogenetic protein (BMP) signaling networks vary drastically in different animal groups ...
Grigory Genikhovich +8 more
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Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
, 2014 Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Smith, James C. +15 more
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The Role of BMP Signaling in Osteoclast Regulation [PDF]
Journal of Developmental Biology, 2021 The osteogenic effects of Bone Morphogenetic Proteins (BMPs) were delineated in 1965 when Urist et al. showed that BMPs could induce ectopic bone formation. In subsequent decades, the effects of BMPs on bone formation and maintenance were established. BMPs induce proliferation in osteoprogenitor cells and increase mineralization activity in osteoblasts.
Brian Heubel, Anja Nohe
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Limitations of bone formation in oral implantology: inhibition of osteoblast functions by gingival tissues [PDF]
, 2010 PhDClinical observation suggest that bone formation is influenced by the environmental niche where it takes place and specifically that soft connective tissues may inhibit the bone healing process.
Al-Masri, Maher
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Interlinked signaling feedback loops and self-regulation during vertebrate limb development [PDF]
, 2009 Reliable organ and tissue morphogenesis seems to depend on self-regulatory mechanisms that are able to buffer spontaneous and/or genetic variations. While the analysis of the interactions of BMPs with their antagonists during gastrulation has provided ...
Bénazet, Jean-Denis
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BMP signalling in craniofacial development
The International Journal of Developmental Biology, 2006 The BMP signalling pathway is conserved throughout evolution and essential for mammalian embryonic and postnatal development and growth. In the vertebrate head, this signal is involved in the development of a variety of structures and shows divergent roles.
Xuguang, Nie +2 more
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A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. [PDF]
PLoS ONE, 2012 Insights into Bone morphogenetic protein (Bmp) functions during forebrain development have been limited by a lack of Bmp signaling readouts. Here we used a novel Bmp signaling reporter ("BRE-gal" mice) to study Bmp signaling in the dorsal telencephalon ...
Linda T Doan +5 more
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