Results 21 to 30 of about 905,740 (294)
BMP signaling in cancer stemness and differentiation. [PDF]
Cell Regen, 2023 AbstractThe BMP (Bone morphogenetic protein) signaling pathway plays a central role in metazoan biology, intricately shaping embryonic development, maintaining tissue homeostasis, and influencing disease progression. In the context of cancer, BMP signaling exhibits context-dependent dynamics, spanning from tumor suppression to promotion.
Zhou W, Yan K, Xi Q.
europepmc +4 more sources
BRITER: a BMP responsive osteoblast reporter cell line. [PDF]
PLoS ONE, 2012 BACKGROUND: BMP signaling pathway is critical for vertebrate development and tissue homeostasis. High-throughput molecular genetic screening may reveal novel players regulating BMP signaling response while chemical genetic screening of BMP signaling ...
Prem Swaroop Yadav +2 more
doaj +1 more source
Biology of BMP signalling and cancer [PDF]
Clinical and Translational Oncology, 2009 In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their malignant properties (i.e., capacity for regrowth and metastasis), are the cancer stem cells (CSCs).
Blanco, Moisés +5 more
openaire +3 more sources
BMP signaling in axon regeneration [PDF]
Current Opinion in Neurobiology, 2014 Neuronal competence to re-extend axons and a permissive environment that allows growth cone navigation are two major determinants for successful axon regeneration. Here, we review the roles of bone morphogenetic protein (BMP) signaling in mediating both neuronal and glial injury responses after CNS injury.
Jian, Zhong, Hongyan, Zou
openaire +2 more sources
Extracellular regulation of BMP signaling [PDF]
Current Biology, 2010 In the developing organism, cells differentiate, divide and die as part of groups of hundreds or thousands of cells called 'morphogenetic fields'. Fields have the remarkable property of self-regulation: for example, if the forelimb field is bisected, each half can give rise to a complete limb after transplantation, as discovered by Ross Harrison in ...
Zakin, Lise, De Robertis, E.M.
openaire +2 more sources
Frontiers in Physiology, 2023 Cranial neural crest cells (NCCs) are the origin of the anterior part of the face and the head. Cranial NCCs are multipotent cells giving rise to bones, cartilage, adipose-tissues in the face, and neural cells, melanocytes, and others.
Hiroki Ueharu, Yuji Mishina
doaj +1 more source
Epithelial-mesenchymal feedback signalling during vertebrate organogenesis : genetic analysis of BMP-Gremlin1 antagonistic interactions [PDF]
, 2010 Branching morphogenesis of the metanephric kidney relies on an intricate molecular system that controls a highly regulated developmental program. Metanephric kidney organogenesis involves a complex system of epithelial mesenchymal interactions that ...
Gonçalves, Alexandre
core +1 more source
Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. [PDF]
PLoS ONE, 2013 Bone morphogenetic proteins (BMPs) are highly conserved morphogens that are essential for normal development. BMP-2 is highly expressed in the majority of non-small cell lung carcinomas (NSCLC) but not in normal lung tissue or benign lung tumors.
Elaine Langenfeld +3 more
doaj +1 more source
Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]
, 2010 Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde +4 more
core +1 more source
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. [PDF]
PLoS ONE, 2015 Bone Morphogenetic Proteins (BMPs) form a group of secreted factors that belongs to the TGF-β superfamily. Among different roles in a number of immune cell types, BMPs are known to regulate T cell development within the thymus, although the role of BMP ...
Víctor G Martínez +7 more
doaj +1 more source