Results 1 to 10 of about 905,740 (294)

BMP Signaling Pathway in Dentin Development and Diseases

Cells, 2022
BMP signaling plays an important role in dentin development. BMPs and antagonists regulate odontoblast differentiation and downstream gene expression via canonical Smad and non-canonical Smad signaling pathways.
Mengmeng Liu, Graham Goldman, Mary MacDougall, Shuo Chen   +3 more
doaj   +2 more sources

The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning. [PDF]

PLoS Biology
In Bilateria with centralized nervous systems (e.g., in vertebrates or arthropods), the minimum of the BMP signaling activity gradient defines the position of the central nervous system.
Paul Knabl, June F Ordoñez, Juan Daniel Montenegro Cabrera, Daniel Abed-Navandi, Roland Halbauer, Oliver Link, Tim Wollesen, Grigory Genikhovich   +7 more
doaj   +2 more sources

The BMP signaling gradient is interpreted through concentration thresholds in dorsal–ventral axial patterning

PLoS Biology, 2021
Bone Morphogenetic Protein (BMP) patterns the dorsal-ventral (DV) embryonic axis in all vertebrates, but it is unknown how cells along the DV axis interpret and translate the gradient of BMP signaling into differential gene activation that will give rise
Jerome Lin, Mary C Mullins, Hannah Greenfeld   +2 more
exaly   +2 more sources

An Intermediate Level of BMP Signaling Directly Specifies Cranial Neural Crest Progenitor Cells in Zebrafish

PLoS ONE, 2011
The specification of the neural crest progenitor cell (NCPC) population in the early vertebrate embryo requires an elaborate network of signaling pathways, one of which is the Bone Morphogenetic Protein (BMP) pathway. Based on alterations in neural crest
Jennifer Schumacher, Mary C Mullins
exaly   +3 more sources

A whole-body atlas of BMP signaling activity in an adult sea anemone [PDF]

BMC Biology
Background BMP signaling is responsible for the second body axis patterning in Bilateria and in the bilaterally symmetric members of the bilaterian sister clade Cnidaria—corals and sea anemones.
Paul Knabl, David Mörsdorf, Grigory Genikhovich   +2 more
doaj   +2 more sources

Positional BMP signaling orchestrates villus length in the small intestine [PDF]

Nature Communications
The intestinal epithelium undergoes fast turnover, and the villus length in the small intestine gradually decreases from the duodenum to the ileum. However, the underlying mechanisms remain poorly understood.
Xu Wang, Siqi Li, Yuan Liu, Xiangyu Kuang, Jianxin Chen, Pei Yu, Lianzheng Zhao, Ze Zhang, Meimei Huang, Liansheng Liu, Mengxian Zhang, Yalong Wang, Weizhi Ji, Jinsong Li, Lei Zhang, Ye-Guang Chen   +15 more
doaj   +2 more sources

Unanswered Questions Regarding Sex and BMP/TGF-β Signaling

Journal of Developmental Biology, 2018
Crosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-&
Melissa B Rogers
exaly   +3 more sources

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress [PDF]

Nature Communications
In contrast to mammals, adult zebrafish achieve complete heart regeneration via proliferation of cardiomyocytes. Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue ...
Mohankrishna Dalvoy Vasudevarao, Denise Posadas Pena, Michaela Ihle, Chiara Bongiovanni, Pallab Maity, Dominik Geissler, Hossein Falah Mohammadi, Melanie Rall-Scharpf, Julian Niemann, Mathilda T. M. Mommersteeg, Simone Redaelli, Kathrin Happ, Chi-Chung Wu, Arica Beisaw, Karin Scharffetter-Kochanek, Gabriele D’Uva, Mona Malek Mohammadi, Lisa Wiesmüller, Hartmut Geiger, Gilbert Weidinger   +19 more
doaj   +2 more sources

Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans

Cell & Bioscience, 2022
Background Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer’s disease, obesity, and cardiovascular disease.
Mehul Vora, Arindam Mondal, Dongxuan Jia, Pranya Gaddipati, Moumen Akel, John Gilleran, Jacques Roberge, Christopher Rongo, John Langenfeld   +8 more
doaj   +1 more source

Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2017
The highly conserved bone morphogenetic protein (BMP) signaling pathway regulates many developmental and homeostatic processes. While the core components of the BMP pathway have been well studied, much research is needed for understanding the mechanisms ...
Lin Wang, Zhiyu Liu, Herong Shi, Jun Liu
doaj   +1 more source