Results 11 to 20 of about 905,740 (294)

Specification of BMP signaling [PDF]

Cells, 2019
Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor (TGF)β family and represent secreted growth factors, which play an essential role in many aspects ...
Mueller, Thomas D., Thomas D. Mueller, Joachim Nickel, Nickel, Joachim   +3 more
core   +3 more sources

BMP signaling in vascular diseases [PDF]

FEBS Letters, 2012
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors.
Cai, J., Sánchez-Duffhues, Gonzalo, Cai, Jie, Peter ten Dijke, Gonzalo Sánchez-Duffhues, Pardali, E., Pardali, Evangelia, Jie Cai, Dijke, P. ten, Evangelia Pardali, Sanchez-Duffhues, G., ten Dijke, Peter   +11 more
core   +5 more sources

Optogenetic Control of the BMP Signaling Pathway [PDF]

ACS Synthetic Biology, 2020
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β (TGFβ) superfamily and have crucial roles during development; including mesodermal patterning and specification of renal, hepatic, and skeletal tissues.
Lucas, Robert; id_orcid, Kimber, Susan; id_orcid, Woods, Steven; id_orcid, Cain, Stuart; id_orcid, Bates, Nicola; id_orcid, Smith, Christopher, Humphreys, Paul   +6 more
core   +5 more sources

The Role of BMP Signaling in Endothelial Heterogeneity [PDF]

Frontiers in Cell and Developmental Biology, 2021
Bone morphogenetic proteins (BMPs), which compose the largest group of the transforming growth factor-β (TGF-ß) superfamily, have been implied to play a crucial role in diverse physiological processes. The most intriguing feature of BMP signaling is that
Orjin Han, Boryeong Pak, Suk-Won Jin
doaj   +3 more sources

BMP signaling controls muscle mass.

Nature Genetics, 2013
Cell size is determined by the balance between protein synthesis and degradation. This equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and cytokines.
Arnaud Ferry, Amalia Stantzou, Sandri, M., Bortolanza, S., Etienne Mouisel, Enzo E., Stricker S, Stricker S., Goldberg A. L., DUPONT, SIRIO, Alfred L Goldberg, Sergia Bortolanza, Stantzou A, Elena Enzo, Goldberg AL, Amthor H, Dupont S., Stefano Piccolo, Ferry A., Roberta Sartori, Ferry, A., PICCOLO, STEFANO, Sartori R, Toniolo L., Dupont, S., Blaauw B., Schirwis E, TONIOLO, LUANA, Zhao J., Bert Blaauw, Stricker, S., Schirwis E., Enzo, E., Toniolo, L., Mouisel E, Marco Sandri, Goldberg, A.L., Schirwis, E., Mouisel, E., Ferry A, Piccolo S., Luana Toniolo, Bortolanza S., Amthor H., Elija Schirwis, Zhao J, Helge Amthor, Stantzou A., Amthor, H., Blaauw, B., SANDRI, MARCO, Sandri M., Bortolanza S, Sirio Dupont, Sartori R., ENZO, ELENA, Jinghui Zhao, Sigmar Stricker, BLAAUW, BERT, Sartori, R., Piccolo, S., Mouisel E., Zhao, J., Stantzou, A.   +63 more
core   +4 more sources

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]

, 2013
Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Crawford, Alexander D, Cordero-Maldonado, María Lorena, Clements, Carol, de Witte, Peter A M, Edrada-Ebel, Ruangelie, Gray, Alexander I, Esguerra, Camila V, Gebruers, Evelien, Harvey, Alan L   +8 more
core   +4 more sources

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma. [PDF]

Cell Death Differ
Oncogenic events perturb cerebellar development leading to medulloblastoma, a common childhood brain malignancy. Molecular analyses classify medulloblastoma into the WNT, SHH, Group 3 and Group 4 subgroups.
Ohata Y, Ali MM, Tsubakihara Y, Itoh Y, Rosén G, Bergström T, Morén A, Golán-Cancela I, Nakada A, Voytyuk O, Tsuchiya M, Fukui R, Yamamoto K, Martín-Rubio P, Sancho P, Strell C, Micke P, Wechsler-Reya RJ, Hashizume Y, Miyazono K, Caja L, Heldin CH, Swartling FJ, Moustakas A.   +23 more
europepmc   +2 more sources

BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells

Frontiers in Cell and Developmental Biology, 2020
The bone morphogenetic protein (BMP) signaling pathway is highly conserved across many species, and its importance for the patterning of the skeletal system has been demonstrated.
Guiqian Chen, Haodong Xu, Yifeng Yao, Tingting Xu, Mengting Yuan, Xingen Zhang, Zhengbing Lv, Mengrui Wu   +7 more
doaj   +1 more source

BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors. [PDF]

PLoS Genetics, 2018
A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire (hiw ...
Ken Honjo, W Daniel Tracey
doaj   +1 more source

Optogenetic investigation of BMP target gene expression diversity

eLife, 2020
Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis.
Katherine W Rogers, Mohammad ElGamacy, Benjamin M Jordan, Patrick Müller   +3 more
doaj   +1 more source