Roles of TGFβ signaling Smads in squamous cell carcinoma
Cell & Bioscience, 2011 Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. Smad1/5/8 mainly mediate bone morphogenetic proteins (BMP) pathway and Smad2/3 mainly mediate TGFβ pathway.
Han Gangwen, Wang Xiao-Jing
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A novel BR-SMAD is required for larval development in barber’s pole worm Haemonchus contortus
Microbial Cell, 2020 SMAD proteins mediate TGF-β signaling and thereby regulate the metazoan development; however, they are poorly defined in Haemonchus contortus–a common blood-sucking parasitic nematode of small ruminants. Here, we characterized an R-SMAD family protein in
Fangfang Li +4 more
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WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets [PDF]
, 2011 A number of recent papers on the WWP2 E3 ubiquitin ligase and two novel WWP2 isoforms have revealed important biological insight and disease-specific functions, and also impacted on our understanding of ubiquitin ligases in cell cycle regulation ...
Chantry, A
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Frontiers in Pharmacology, 2023 Objective: To clarify the potential therapeutic effects of thymoquinone (TQ) on pancreatic cancer and its gemcitabine (GEM) sensitivity.Methods: The expression levels of hypoxia inducible factor-1α (HIF-1α), collagens (COL1A1, COL3A1, and COL5A1), and ...
Zhanxue Zhao +8 more
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Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage. [PDF]
, 2006 Osteoarthritis is a common malady of the musculoskeletal system affecting the articular cartilage. The increased frequency of osteoarthritis with aging indicates the complex etiology of this disease, which includes pathophysiology and joint stability ...
Reddi, A Hari
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Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins [PDF]
Nucleic Acids Research, 2001 An emerging theme in transforming growth factor-ss (TGF-ss) signalling is the association of the Smad proteins with diverse groups of transcriptional regulatory proteins. Several Smad cofactors have been identified to date but the diversity of TGF-ss effects on gene transcription suggests that interactions with other co-regulators must occur.
Z A, Quinn +3 more
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Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad
Cell & Bioscience, 2011 Smad proteins are the intracellular mediators of transforming growth factor β (TGF-β) signaling. Smads function as transcription factors and their activities require carboxyl-terminal phosphorylation by TGF-β receptor kinases which are embedded in the ...
Chen Xiaochu, Xu Lan
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Current perspectives of the signaling pathways directing neural crest induction. [PDF]
, 2012 The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I +1 more
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Cooperative assembly of Co-Smad4 MH1 with R-Smad1/3 MH1 on DNA: a molecular dynamics simulation study. [PDF]
PLoS ONE, 2013 BackgroundSmads, the homologs of Sma and MAD proteins, play a key role in gene expression regulation in the transforming growth factor-β (TGF-β) signaling pathway.
Guihong Wang +3 more
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Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. [PDF]
, 2007 OBJECTIVE: The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes.
Jimenez, Sergio A. +2 more
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