Results 21 to 30 of about 119,459 (302)
CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription [PDF]
Molecular and Cellular Biology, 2004 Transforming growth factor beta (TGF-beta)/bone morphogenetic protein (BMP) family ligands interact with specific membrane receptor complexes that have serine/threonine kinase activities. The receptor phosphorylation and activation induced by the ligands leads to phosphorylation of the Smad proteins, which translocate to the nucleus, controlling gene ...
Linyu, Li +8 more
openaire +2 more sources
Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding
iScience, 2022 Summary: A delicate balance of BMP activity is critical for tissue formation and organogenesis. However, the mechanical molecular details in ensuring the proper duration and intensity of BMP signaling have yet to be fully elucidated.
Shuyan Yang +7 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2022 Ankylosing spondylitis (AS) is a refractory autoimmune disease, whose typical pathology is the development of inflammation to ossification and ankylosis.
Yong Zeng +7 more
doaj +1 more source
Brazilian Neurosurgery, 2023 Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade ...
Güven Gürsoy +4 more
doaj +1 more source
SMAD proteins control DROSHA-mediated microRNA maturation [PDF]
Nature, 2008 MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA and protein synthesis. Aberrant miRNA expression leads to developmental abnormalities and diseases, such as cardiovascular disorders and cancer; however, the stimuli and processes regulating miRNA biogenesis are largely unknown.
Brandi N, Davis +3 more
openaire +2 more sources
Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins [PDF]
Open Biology, 2012 Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3.
Elizabeth M. Callery +5 more
doaj +1 more source
Nucleocytoplasmic shuttling of Smad proteins [PDF]
Cell Research, 2008 Nuclear accumulation of active Smad complexes is crucial for transduction of transforming growth factor beta (TGF-beta)-superfamily signals from transmembrane receptors into the nucleus. It is now clear that the nucleocytoplasmic distributions of Smads, in both the absence and the presence of a TGF-beta-superfamily signal, are not static, but instead ...
openaire +2 more sources
Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling [PDF]
Journal of Biological Chemistry, 2016 TGF-β is a pleiotropic cytokine that regulates a wide range of cellular actions and pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key negative regulator of TGF-β signaling, Smad7 exerts its inhibitory effects by blocking receptor activity, inducing receptor degradation or interfering with Smad-DNA binding.
Xiaohua, Yan +6 more
openaire +2 more sources
Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]
, 2010 Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Lo, Angela K. F. +4 more
core +2 more sources
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus [PDF]
Open Biology, 2017 Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance, differentiation and embryonic development. Intracellularly, BMP signalling is mediated by Smad proteins, which are regulated post-transcriptionally through ...
Pengcheng Ma +7 more
doaj +1 more source