Results 31 to 40 of about 119,459 (302)

Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. [PDF]

, 2014
We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary ...
Barakat, Nermeen H, Breen, Kellie M, Coss, Djurdjica, Hambarchyan, Arpi, Meadows, Jason D, Mellon, Pamela L, Pepa, Patricia A, Roybal, Lacey L   +7 more
core   +1 more source

Regulation of cell proliferation by Smad proteins [PDF]

Journal of Cellular Physiology, 2002
AbstractTransforming growth factor‐β (TGF‐β) family members which include TGF‐βs, activins, and bone morphogenetic proteins (BMPs) regulate a broad spectrum of biological responses on a large variety of cell types. TGF‐β family members initiate their cellular responses by binding to distinct receptors with intrinsic serine/threonine kinase activity and
Peter, Ten Dijke, Marie-José, Goumans, Fumiko, Itoh, Susumu, Itoh   +3 more
openaire   +2 more sources

Conformational landscape of full-length Smad proteins [PDF]

, 2021
AbstractSmad transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have been shaped along the evolution of multicellular animals to regulate essential processes. Smad proteins have a mixed architecture of globular domains and flexible linkers and adopt distinct quaternary structures depending on their activation ...
Tiago Gomes, Pau Martin-Malpartida, Lidia Ruiz, Eric Aragón, Tiago N. Cordeiro, Maria J. Macias   +5 more
openaire   +1 more source

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Pin1 Protein Regulates Smad Protein Signaling and Pulmonary Fibrosis [PDF]

Journal of Biological Chemistry, 2012
Interstitial pulmonary fibrosis is caused by the excess production of extracellular matrix (ECM) by Fb in response to TGF-β1. Here, we show that the peptidyl-prolyl isomerase Pin1 modulates the production of many pro- and antifibrogenic cytokines and ECM.
Zhong-Jian, Shen, Ruedi K, Braun, Jie, Hu, Qifa, Xie, Haiyan, Chu, Robert B, Love, Levi A, Stodola, Louis A, Rosenthal, Renee J, Szakaly, Ronald L, Sorkness, James S, Malter   +10 more
openaire   +2 more sources

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

Cells, 2014
TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their ...
Feng Xie, Zhengkui Zhang, Hans van Dam, Long Zhang, Fangfang Zhou   +4 more
doaj   +1 more source

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis

Frontiers in Pharmacology, 2022
Chronic kidney disease (CKD) was a major public health problem worldwide. Renal fibrosis, especially tubulointerstitial fibrosis, is final manifestation of CKD.
Xiao-Yong Yu, Qian Sun, Ya-Mei Zhang, Liang Zou, Ying-Yong Zhao   +4 more
doaj   +1 more source

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal, Akech, Ali, Aqeilan, Bamba, Begley, Buijs, Calon, Campbell, Casimiro, D'Alonzo, Deng, Dutta, Eswaraka, Fradet, Furuya, Gordon, Hess, Huang, Ikushima, Iranikhah, Javed, Kamradt, Kang, Koeneman, Lay, Leong, Massague, Mathew, Matsumoto, Matsumura, McCoy, Mendoza-Villanueva, Morrissey, Necula, Ortiz, Padua, Pratap, Pratap, Pratap, Schroeder, Selvamurugan, Shen, Sottnik, Stein, Tang, Tang, Tohjima, van der Deen, Wan, Weilbaecher, Xiang, Yang, Yang, Yang, Young, Zaidi, Zhang, Zhang, Zurita   +59 more
core   +2 more sources

Resveratrol treatment ameliorates hepatic damage via the TGF-β/SMAD signaling pathway in a phenobarbital/CCl4-induced hepatic fibrosis model [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Liver fibrosis is a wound healing response characterized by excessive accumulation of extracellular matrix proteins. This study aimed to investigate the effects of resveratrol treatment on the TGF-β/SMAD signaling pathway and related ...
Merve Aykaç, Eda Balkan, Semin Gedi̇kli, Nurinnisa Öztürk   +3 more
doaj   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source