Results 51 to 60 of about 119,459 (302)

SMAD versus Non-SMAD Signaling Is Determined by Lateral Mobility of Bone Morphogenetic Protein (BMP) Receptors [PDF]

Journal of Biological Chemistry, 2012
Bone (or body) morphogenetic proteins (BMPs) belong to the TGFβ superfamily and are crucial for embryonic patterning and organogenesis as well as for adult tissue homeostasis and repair. Activation of BMP receptors by their ligands leads to induction of several signaling cascades.
Guzman, A., Zelman-Femiak, M., Boergermann, J., Paschkowsky, S., Kreuzaler, P., Fratzl, P., Harms, G., Knaus, P.   +7 more
openaire   +3 more sources

Asiaticoside Combined With Carbon Ion Implantation to Improve the Biocompatibility of Silicone Rubber and to Reduce the Risk of Capsule Contracture

Frontiers in Bioengineering and Biotechnology, 2022
Capsular contracture caused by silicone rubber is a critical issue in plastic surgery that urgently needs to be solved. Studies have shown that carbon ion implant in silicone rubber (carbon silicone rubber, C-SR) can significantly improve the capsular ...
Xing Liu, Ya-Jun Song, Xing Chen, Meng-Ya Huang, Chen-Xi Zhao, Xun Zhou, Xin Zhou   +6 more
doaj   +1 more source

Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. [PDF]

PLoS ONE, 2010
We have recently described that in an experimental model of atherosclerosis and in vascular smooth muscle cells (VSMCs) statins increased the activation of the Smad pathway by transforming growth factor-β (TGF-β), leading to an increase in TGF-β ...
Raúl Rodrigues Díez, Raquel Rodrigues-Díez, Carolina Lavoz, Sandra Rayego-Mateos, Esther Civantos, Juan Rodríguez-Vita, Sergio Mezzano, Alberto Ortiz, Jesús Egido, Marta Ruiz-Ortega, Marta Ruiz-Ortega   +10 more
doaj   +1 more source

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling [PDF]

, 2011
Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in
A Tagariello, AK Cheung, AN Kapustin, AP Sage, BA Willems, C Hough, C Surmann-Schmitt, C-H Heldin, CA Gregory, CM Giachelli, CM Shanahan, CM Shanahan, CM Shanahan, CR Dhore, CS Viegas, CS Viegas, CS Viegas, D Proudfoot, E Neven, F Guerrero, F Liu, JL Hunt, KM McCabe, LJ Schurgers, LJ Schurgers, LS Shankman, M Jeune Le, M Mizobuchi, MG Frid, MJ Duer, ML Chatrou, MR Alexander, MS Rafael, MY Speer, N Eitzinger, QQ Huang, R Shroff, RJ Rennenberg, S Feil, S Jono, S Olechnowicz-Tietz, SA Steitz, T Cai, T Lin, VA Jesus Perez de, VP Iyemere, X Li, Y Liu, YJ Lee   +48 more
core   +2 more sources

Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo [PDF]

, 2007
The TGF-beta-related molecule Nodal plays an essential and conserved role in left-right patterning of the vertebrate embryo. Previous reports have shown that the zebrafish and mouse Cerberus-related proteins Charon and Cerberus-like-2 (Cerl-2 ...
Andrade, Sofia, Belo, José A., Silva, Ana Cristina, Tavares, Ana Teresa   +3 more
core   +1 more source

microRNA are central players in anti- and profibrotic gene regulation during liver fibrosis.

Frontiers in Physiology, 2012
miRNA are small noncoding RNA molecules that posttranscriptionally effect mRNA stability and translation by targeting the 3´-untranslated region (3`-UTR) of various transcripts. Thus, dysregulation of miRNA affects a wide range of cellular processes
Andrea eNoetel, Monika eKwiecinski, Natalia eElfimova, Jia eHuang, Margarete eOdenthal   +4 more
doaj   +1 more source

Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. [PDF]

, 2008
OBJECTIVE: Recent studies have implicated caveolin 1 in the regulation of transforming growth factor beta (TGFbeta) downstream signaling. Given the crucial role of TGFbeta in the pathogenesis of systemic sclerosis (SSc), we sought to determine whether ...
de Almeida, Cecilia J., Del Galdo, Francesco, Jasmin, Jean-Francois, Jimenez, Sergio A., Lisanti, Michael P., Musick, Megan, Sotgia, Federica   +6 more
core   +2 more sources

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo [PDF]

Cytokine & Growth Factor Reviews, 2011
Signaling by the many ligands of the TGFβ family strongly converges towards only five receptor-activated, intracellular Smad proteins, which fall into two classes i.e. Smad2/3 and Smad1/5/8, respectively. These Smads bind to a surprisingly high number of Smad-interacting proteins (SIPs), many of which are transcription factors (TFs) that co-operate in ...
Conidi, Andrea, Cazzola, Silvia, Beets, Karen, Coddens, Kahleen, Collart, Clara, Cornelis, Frederique, Cox, Luk, Debruyn, Joke, Dobreva, Mariya, Dries, Ruben, Lesage, Flore, Maas, Elke, Moya, Iván, Pereira, Paulo N.G., Stappers, Elke, Stryjewska, Agata, Esguerra, Camila, Francis, Annick, Ibrahimi, Abdelilah, Kroes, Reol, van den Berghe, Veronique, Vermeire, Liesbeth, Verstappen, Griet, Seuntjens, Eve, Umans, Lieve, Zwijsen, An, Huylebroeck, Danny   +26 more
openaire   +3 more sources

Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors

Pharmaceuticals
SMADs are the canonical intracellular effector proteins of the TGF-β (transforming growth factor-β). SMADs translocate from plasma membrane receptors to the nucleus regulated by many SMAD-interacting proteins through phosphorylation and other post ...
Farhana Runa, Gabriela Ortiz-Soto, Natan Roberto de Barros, Jonathan A. Kelber   +3 more
doaj   +1 more source

Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.

PLoS ONE, 2019
Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency.
Jana Frýdlová, Daniel W Rogalsky, Jaroslav Truksa, Emanuel Nečas, Martin Vokurka, Jan Krijt   +5 more
doaj   +1 more source