Stem Cells International, 2022 Heterotopic ossification (HO) is defined as the formation of bone tissues outside the bones, such as in the muscles. Currently, the mechanism of HO is still unclear.
Junchao Huang +4 more
doaj +1 more source
PLoS ONE, 2020 Recent studies have demonstrated the implication of long noncoding RNAs (lncRNAs) in a variety of physiological and pathological processes. However, the majority of lncRNAs are functionally unknown.
Jinqiang Zhang +7 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Cardiac fibrosis is a serious public health problem worldwide that is closely linked to progression of many cardiovascular diseases (CVDs) and adversely affects both the disease process and clinical prognosis.
Chunjun Li +3 more
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Atorvastatin’s Therapeutic Potential in Atherosclerosis: Inhibiting TGF-β-Induced Proteoglycan Glycosaminoglycan Chain Elongation through ROS-ERK1/2-Smad2L Signaling Pathway Modulation in Vascular Smooth Muscle Cells [PDF]
Cell JournalObjective: According to the response-to-retention hypothesis, the inception of atherosclerosis is attributed to thedeposition and retention of lipoprotein in the arterial intima, facilitated by altered proteoglycans with hyperelongatedglycosaminoglycan ...
Hossein Ghaderi-Zefrehi +4 more
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Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection. [PDF]
PLoS ONE, 2018 Rift Valley fever virus (RVFV) infects both ruminants and humans leading to a wide variance of pathologies dependent on host background and age. Utilizing a targeted reverse phase protein array (RPPA) to define changes in signaling cascades after in ...
Cynthia de la Fuente +11 more
doaj +1 more source
Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway [PDF]
Endocrinology and Metabolism, 2020 Background Endothelial-to-mesenchymal transition (EndMT) contributes to inflammatory conditions inducing conversion of endothelial cells (ECs) into activated fibroblasts, promoting fibrotic diseases.
Oak-Kee Hong +7 more
doaj +1 more source
Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]
, 2019 The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole +5 more
core +1 more source
Holding Their Own: The Noncanonical Roles of Smad Proteins [PDF]
Science Signaling, 2008 There are TGF-β–independent regulatory mechanisms and functions of Smads.
Loretta L, Hoover, Steven W, Kubalak
openaire +2 more sources
Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN. [PDF]
, 2001 This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis.
Reddi, AH
core
Systemic sclerosis: current views of its pathogenesis. [PDF]
, 2003 Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities ...
Derk, Chris T., Jimenez, Sergio A.
core +2 more sources