Results 71 to 80 of about 6,494 (198)

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment

Immunology &Cell Biology, Volume 104, Issue 7, Page 711-728, August 2026.
Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari, Farah Ahmady‐Nield, Amit Sharma, Ingo G. H. Schmidt‐Wolf, Jarek Maciaczyk, Rodney B. Luwor, Adrian A. Achuthan   +6 more
wiley   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, Volume 13, Issue 39, 13 July 2026.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Organocatalytic B–H Functionalization of Carboranes via Photo‐Induced Hydrogen Atom Transfer

ChemistryEurope, Volume 4, Issue 7, July 2026.
Visible‐light organocatalytic hydrogen atom transfer enables direct carborane B─H bond functionalization. A photocatalytically generated cationic aminium radical selectively abstracts hydrogen from hydridic boron sites, forming boron‐centered radicals that couple with activated olefins or imines to deliver B‐functionalized carboranes under mild ...
Takaya Sakaue, Kana Yasuda, Tsukasa Tawatari, Akira Matsumoto, Keiichi Hirano, Kiyosei Takasu, Hiroshi Takikawa   +6 more
wiley   +1 more source

Melanoma cell death after BNCT.

, 2013
(A) Tumor volume of mice bearing B16F10 melanoma during twenty-one days. On the fourteenth day after B16F10 melanoma implantation, the BNCT group received BPA and was irradiated with thermal neutrons.
Silvya Stuchi Maria-Engler (177184), Fernanda Faião-Flores (392392), Paulo Rogério Pinto Coelho (392393), Vera Luiza Capelozzi (392396), Durvanei Augusto Maria (389698), Ricardo Rodrigues Giorgi (392397), João Dias Toledo Arruda-Neto (392394), Manoela Tiago (392395)   +7 more
core   +1 more source

Optimization of BNCT for thyroid cancer treatment [PDF]

, 2018
BNCT es una radioterapia para el cáncer. Se basa en la reacción 10B (n, α) 7Li utilizando el compuesto borado BPA. Las partículas resultantes (alta LET) provocan DSBs (Double Strand Breaks) en el ADN que pueden ser reparadas por las vías homologous ...
Rodríguez, Carla Beatriz
core   +2 more sources

Hematoxylin and eosin-stained sections of malignant melanoma in control, irradiated control, BNCT 1 and BNCT 7 days groups.

, 2013
In the control and irradiated groups, malignant melanoma cells were preserved and composed of large cells with atypical nuclei and abundant cytoplasm. Normal mitosis (blue arrows) and aberrant mitosis (yellow arrows) were both observed.
Silvya Stuchi Maria-Engler (177184), Fernanda Faião-Flores (392392), Paulo Rogério Pinto Coelho (392393), Vera Luiza Capelozzi (392396), Durvanei Augusto Maria (389698), Ricardo Rodrigues Giorgi (392397), João Dias Toledo Arruda-Neto (392394), Manoela Tiago (392395)   +7 more
core   +1 more source

Boron neutron capture therapy (BNCT) for the treatment of oral cancer: development of new BNCT protocols, evaluation of radiobiology, therapeutic efficacy and radiotoxicity in a hamster model [PDF]

, 2013
La Captura Neutrónica en Boro (BNCT) es una terapia binaria que se basa en la acumulación selectiva de compuestos borados dentro del tumor y la subsiguiente irradiación con neutrones térmicos.
Molinari, Ana Julia
core   +1 more source

33S as a cooperative capturer for BNCT

Applied Radiation and Isotopes, 2014
(33)S is a stable isotope of sulfur for which the emission of an α-particle is the dominant exit channel for neutron-induced reactions. In this work the enhancement of both the absorbed and the equivalent biologically weighted dose in a BNCT treatment with 13.5keV neutrons, due to the presence of (33)S, has been tested by means of Monte Carlo ...
Ignacio Porras, Javier Praena, Javier Praena, Pedro L. Esquinas, Pierfrancesco Mastinu, J. M. Quesada, M. Sabaté-Gilarte, M. Sabaté-Gilarte   +7 more
openaire   +4 more sources

In Vivo Efficacy Test of the BNCT Treatment Mediated by an Innovative Dual GadoLinium/Boron Agent

, 2011
An innovative dual BNCT agent (Gd/B/L-LDL) was developed and its efficacy as 10B carrier was tested by some in vivo irradiations at the TRIGA reactor in Pavia.
BORTOLUSSI, SILVA, ALTIERI, SAVERIO, Silvio Aime, Sabrina Stella, Piero Bruschi, Simonetta Geninatti Crich, Diego Alberti, PROTTI, NICOLETTA, BALLARINI, FRANCESCA   +8 more
core  

Preliminary outcomes of boron neutron capture therapy for head and neck cancers as a treatment covered by public health insurance system in Japan: Real‐world experiences over a 2‐year period

Cancer Medicine
Purpose Since June 2020, boron neutron capture therapy (BNCT) has been a health care service covered by health insurance in Japan to treat locally advanced or recurrent unresectable head and neck cancers.
Satoshi Takeno, Yuki Yoshino, Teruhito Aihara, Masaaki Higashino, Yasukazu Kanai, Naonori Hu, Ryo Kakino, Ryo Kawata, Keiji Nihei, Koji Ono   +9 more
doaj   +1 more source