Results 241 to 250 of about 21,955 (252)
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Combining biomarkers of BNIP3 L, S100B, NSE, and accessible measures to predict sepsis-associated encephalopathy: a prospective observational study

Current Medical Research and Opinion
Background Accurate identification of delirium in sepsis patients is crucial for guiding clinical diagnosis and treatment. However, there are no accurate biomarkers and indicators at present.
Nannan Zhang   +5 more
semanticscholar   +1 more source

The role of HIF-1α/Bnip3/mitophagy in acrylonitrile-induced neuronal death in HT22 cells and mice: a potential neuroprotection target.

Chemico-Biological Interactions
Acrylonitrile (AN) is a widely utilized organic compound in the production of diverse industrial synthetic materials. While acute exposure to AN can cause neurotoxicity, the precise mechanism remains unclear.
Jing Hu   +14 more
semanticscholar   +1 more source

BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease.

International Journal of Biochemistry and Cell Biology
BNIP3 localizes to the outer mitochondrial membrane, has been demonstrated to be extensively involved in abnormalities to mitochondrial metabolic function and dynamicsand in non-alcoholic fatty liver disease (NAFLD).
M. Tian   +6 more
semanticscholar   +1 more source

Functions of BNIP3 in Nutrient Stress Responses

2019
BNIP3 is a mitophagy receptor that targets mitochondria for degradation at the autophagolysosome. By mediating mitophagy, BNIP3 functions to decrease mitochondrial mass as an adaptive response to stress, namely hypoxia and nutrient starvation. This catabolic mechanism prevents the accumulation of damaging reactive oxygen species that are normally ...
openaire   +1 more source

Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy

Autophagy
Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired ...
Han-Ji Chang   +10 more
semanticscholar   +1 more source

ITGB4/BNIP3 Activates Autophagy and Reduces MHC‐I Expression to Mediate Tumour Immune Escape in Pancreatic Cancer Cell Lines

Immunology
This study attempted to identify the relevant pathways involved in autophagy activation of pancreatic cancer and explore the mechanisms underlying immune evasion.
Xianfei Zhou   +6 more
semanticscholar   +1 more source

RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.

Free Radical Biology & Medicine
BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD) is one of the liver illnesses that may be affected by mitophagy, which is the selective removal of damaged mitochondria.
Yifei Chen   +8 more
semanticscholar   +1 more source

Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species

Cell Death and Differentiation
S. Yamashita   +8 more
semanticscholar   +1 more source

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