Results 191 to 200 of about 27,097 (262)

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand. [PDF]

Cancers (Basel)
Resch V, Gjorgoska M, Hafner E, Bacsa I, Kovács B, Büdefeld T, Hunyadi A, Huliák I, Kiricsi M, Paragi G, Rižner TL, Mernyák E.   +11 more
europepmc   +1 more source

Lcn2 Promotes Ferroptosis in Intracerebral Hemorrhage by Targeting Keap1 Tyr572 and Restricting Nrf2 Activation

MedComm, Volume 7, Issue 9, September 2026.
This study reveals that Lcn2 regulates ferroptosis after ICH via the Keap1/Nrf2 axis. Neuronal Lcn2 deletion reduces lipid peroxidation, restores mitochondrial function, and improves ferroptosis. Keap1 Tyr572Ala mutant acts as a molecular switch whose effects invert with Lcn2 status.
Ya‐nan Dou, Hongkang Hu, Qinghua Li, Guangming Wang, Lijun Hou, Junbin Liu, Buyi Zheng, Ying Li, Guohan Hu, Zhou Fei, Xia Li, Li Wang, Jialiang Wei, Lei Jiang, Xiaowei Fei   +14 more
wiley   +1 more source

Fatty acid-binding protein 5 deficiency impairs alveolar macrophage function and metabolism. [PDF]

J Lipid Res
Ratliff JH, Aviszus K, Addi S, El Kharbili M, Fujaros S, Sasse SK, Vestal BE, Gerber AN, Dobrinskikh E, Gally F.   +9 more
europepmc   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

A Microscale Platform for the Comprehensive Analysis of Bacterial Translation Initiation. [PDF]

Int J Mol Sci
Vinogradova DS, Kasatsky PS, Spiridonova ZA, Leyva S, Sanchez-Castro A, Peñaranda K, Zegarra V, Soriano P, Paleskava A, Milon P, Konevega AL.   +10 more
europepmc   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, Volume 46, Issue 5, Page 1362-1389, September 2026.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero, Manel Bosch, Rodrigo Garcés‐Castellanos, Michael Q. Schottenhamel, Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Justo P. Castaño, Tania García‐Becerra, Elena Rebollo, Marta E. Alberto, Antonio Francés‐Monerris, Vicente Marchán   +11 more
wiley   +2 more sources

Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4. [PDF]

J Mol Med (Berl)
Lin W, Feng X, Chen J, Huo B, Guo X, Yang M, Jiang DS, Yu L, Chen Y.   +8 more
europepmc   +1 more source

Patterns of Autonomous and Conditional Neural Specification for the Brain and Ventral Nerve Cord in Annelida

Evolution &Development, Volume 28, Issue 3, September 2026.
Diagrams of blastomere isolations in Capitella teleta and Platynereis dumerilii showing autonomous head neural tissue (from 1q) and trunk neural tissue (from 2d) as well as a decoupling of D–V axis formation from trunk neural tissue in annelids. ABSTRACT Evolution of central nervous systems is a long‐debated topic.
Nicole B. Webster, Johnny A. Davila‐Sandoval, Allan M. Carrillo‐Baltodano, Skyler Duda, B. Duygu Özpolat, Néva P. Meyer   +5 more
wiley   +1 more source