Results 81 to 90 of about 678,206 (297)

Body fluids and salt metabolism - Part I

Italian Journal of Pediatrics, 2009
There is a high frequency of diarrhea and vomiting in childhood. As a consequence the focus of the present review is to recognize the different body fluid compartments, to clinically assess the degree of dehydration, to know how the equilibrium between ...
Simonetti Giacomo D, Bianchetti Mario G, Bettinelli Alberto   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Density Functional for Anisotropic Fluids [PDF]

, 2002
We propose a density functional for anisotropic fluids of hard body particles. It interpolates between the well-established geometrically based Rosenfeld functional for hard spheres and the Onsager functional for elongated rods.
Allen M P, Barboy B, Barboy B, Berne B J, Carnahan N F, Evans R, Frenkel D, Friederike Schmid, Giorgio Cinacchi, Graf H, Hansen J P, Herzfeld J, Holyst R, Isihara A, Lasher G, Martinez-Raton Y, Mecke K, Mulder B, Onsager L, Parsons J D, Perram J W, Phuong N H, Phuong N H, Phuong N H, Phuong N H, Rosenfeld Y, Rosenfeld Y, Rosenfeld Y, Rosenfeld Y, Samborski A, Tarazona P, Tarazona P, Tarazona P, Van Roij R, Velasco E, Weatherburn C E   +35 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A portable device for studying the effects of fluid flow on degradation properties of biomaterials inside cell incubators. [PDF]

, 2019
A portable device was designed and constructed for studying the properties of biomaterials in physiologically relevant fluids under controllable flow conditions that closely simulate fluid flow inside the body.
Chen, Alex H, Jiang, Wensen, Lin, Jiajia, Liu, Huinan, Pan, Jianwei   +4 more
core   +1 more source

Well-posedness of 2D and 3D swimming models in incompressible fluids governed by Navier--Stokes equations

, 2015
We introduce and investigate the wellposedness of two models describing the self-propelled motion of a "small bio-mimetic swimmer" in the 2D and 3D incompressible fluids modeled by the Navier-Stokes equations.
Cannarsa, Piermarco, Floridia, Giuseppe, Khapalov, Alexandre, Priuli, Fabio S.   +3 more
core   +1 more source

EBOV-RNA test with RT-PCR in ocular fluids of Ebola survivors can help to safely perform cataract surgery [PDF]

, 2018
Since the Ebola virus (EBOV) was discovered in 1976, the recent 2014−2016 Ebola virus disease (EVD) outbreak in West Africa was the largest with 28,600 cases and about 11,300 deaths.
Iozzo, Nicola, Spadea, Leopoldo
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source