Results 71 to 80 of about 2,697,359 (292)

Autologous bone marrow clot as an alternative to autograft for bone defect healing

, 2019
Objectives: Long bone defects often require surgical intervention for functional restoration. The ‘gold standard’ treatment is autologous bone graft (ABG), usually from the patient’s iliac crest.
Cool, Simon M., Tan, T.C., Lim, Z. X. H., Nurcombe, Victor, Hui, J.H., Hui, J. H., Ramruttun, A.K., Ramruttun, A. K., Lim, Z.X.H., Tan, T. C., Rai, B., Teoh, Swee Hin, Nurcombe, V., Teoh, S.H., Cool, S.M.   +14 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pathobiology of Paget’s Disease of Bone [PDF]

, 2014
Paget's disease of bone is characterized by highly localized areas of increased bone resorption accompanied by exuberant, but aberrant new bone formation with the primary cellular abnormality in osteoclasts. Paget's disease provides an important paradigm
Galson, Deborah L., Roodman, G. David
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

French Epistemology and its Revisions: Towards a Reconstruction of the Methodological Position of Foucaultian Discourse Analysis

Forum: Qualitative Social Research, 2007
This article reconstructs epistemology in the tradition of Gaston BACHELARD as one of the main foundations of the methodology of FOUCAULTian discourse analysis.
Rainer Diaz-Bone
doaj  

Ética profesional. Análisis desde el quehacer psicojurídico ecuatoriano

Revista Oficial del Poder Judicial
En la actualidad, donde la palabra corrupción está ligada comúnmente a la falta de valores éticos y morales, así como al deseo desbordado del ser humano de tener por encima de ser, muchos abrigamos la esperanza del despertar, a la luz de la ética y la ...
Mónica Alexandra Francis Bone
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Developing Foucault's Discourse Analytic Methodology

Forum: Qualitative Social Research, 2006
A methodological position for a FOUCAULTian discourse analysis is presented. A sequence of analytical steps is introduced and an illustrating example is offered.
Rainer Diaz-Bone
doaj  

Embedding eSkills in Initial Teacher Training

Teaching in Lifelong Learning: A Journal to Inform and Improve Practice, 2011
The decision to become a teacher is a noble and rewarding choice but it presents individuals with many challenges. Trainee teachers are often overwhelmed by the amount of knowledge they are expected to acquire in order to be an effective teacher ...
Szpytma, Elaine, Bone, Catherine
doaj   +1 more source

Spatial and temporal patterns of bone formation in ectopically pre-fabricated, autologous cell-based engineered bone flaps in rabbits [PDF]

, 2008
Biological substitutes for autologous bone flaps could be generated by combining flap pre-fabrication and bone tissue engineering concepts. Here, we investigated the pattern of neotissue formation within large pre-fabricated engineered bone flaps in ...
Pierer, Gerhard, Oliver Scheufler, Galli, Raffaele, Scheufler, Oliver, Braccini, Alessandra, David J. Wendt, Heberer, Michael, Michael Heberer, Gerhard Pierer, Raffaele Galli, Dirk J. Schaefer, Gasser, Juerg A., Jürg A. Gasser, Martin, Ivan, Ivan Martin, Jaquiery, Claude, Claude Jaquiery, Wendt, David J., Alessandra Braccini, Schaefer, Dirk J.   +19 more
core   +1 more source