HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]
, 2017 Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David +4 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
AgricultureBone metabolism dynamic balance is pivotal to bone formation in broilers. Long photoperiods have resulted in leg bones disorders in broilers. Melatonin (MT) is an essential hormone that protects the growth and development of bones, but the functions of ...
Miao Yu +4 more
doaj +1 more source
Design and motion control of a 6-UPS fully parallel robot for long bone fracture reduction : a thesis presented in partial fulfillment of the requirements for the degree of Master of Engineering in Mechatronics at Massey University [PDF]
, 2007 The incidences of long bone fractures in New Zealand are approximately 1 in 10,000. Long bones such as tibia and femur have complicated anatomic structures, making the realignment of these long bone fractures reliant on the skill of the surgeon.
Wu, Yimin
core
A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling [PDF]
, 2010 In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilizing human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven.
Eyckmans, Jeroen +3 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Developmental plasticity of human foetal femur-derived cells in pellet culture: self assembly of an osteoid shell around a cartilaginous core [PDF]
European Cells & Materials, 2011 This study has examined the osteogenic and chondrogenic differentiation of human foetal femur-derived cells in 3-dimensional pellet cultures. After culture for 21-28 days in osteogenic media, the pellets acquired a unique configuration that consisted of ...
AT El-Serafi +3 more
doaj
Acute disruption of bone marrow B lymphopoiesis and apoptosis of transitional and marginal zone B cells in the spleen following a blood-stage Plasmodium chabaudi infection in mice [PDF]
, 2011 B cells and antibodies are essential for the protective immune response against a blood-stagePlasmodiuminfection. Although extensive research has focused on memory as well as plasma B-cell responses during infection, little is known about how malaria ...
Bockstal, Viki +2 more
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source