Results 121 to 130 of about 1,355,503 (353)

Could CH₃-M6P Be a Potential Dual-Functioning Candidate for Bone Regeneration?

Biomedicines
Background: CI-RM6P has different binding sites with affinities for both M6P and IGF2, plays a role in the regulation of the TGF-β and IGF pathways that is important for controlling cell growth and differentiation.
Fidan Huseynova, Cătălina Ionescu, Frederic Cuisinier, Irada Huseynova, Alamdar Mammadov, Véronique Barragan-Montero   +5 more
doaj   +1 more source

Stimulation of Piezo1 by mechanical signals promotes bone anabolism [PDF]

, 2019
Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood.
Almeida, Maria, Han, Li, Li, Xuehua, Mannen, Erin, Nookaew, Intawat, Silva, Matthew J, Xiong, Jinhu   +6 more
core   +1 more source

ERK-activated kinase RSK2 protects against inflammatory arthritis-induced bone destruction by opposing the tumour necrosis factor α-mediated inhibition of bone formation [PDF]

, 2010
Christian Böhm, Mario M. Zaiss, Roland Axmann, Andreas Heß, Klaus Engelke, George Kollias, Georg Schett, J-P David   +7 more
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Green Tea Extract Containing Epigallocatechin-3-Gallate Facilitates Bone Formation and Mineralization by Alleviating Iron-Overload-Induced Oxidative Stress in Human Osteoblast-like (MG-63) Cells

Antioxidants
Secondary iron overload exacerbates osteoporosis by elevating reactive oxygen species (ROS), which suppress osteoblast function and enhance osteoclast activity, disrupting bone remodeling.
Honghong Xu, Orawan Khantamat, Woranontee Korsieporn, Narisara Paradee, Jin Li, Yanping Zhong, Somdet Srichairatanakool, Pimpisid Koonyosying   +7 more
doaj   +1 more source

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis [PDF]

, 2019
Narelle E. McGregor, Melissa Murat, Jeevithan Elango, Ingrid J. Poulton, Emma C. Walker, Blessing Crimeen‐Irwin, P.W.M. Ho, Jonathan H. Gooi, T. John Martin, Natalie A. Sims   +9 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Polyphenol-rich extract from Wisteria floribunda (Willd.) DC. flowers promotes osteoblast differentiation and bone formation by modulating the mTOR pathway

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the osteogenic effects of polyphenol-rich extracts from Wisteria floribunda (Willd.) DC. (W. floribunda) flowers and elucidate the underlying mechanisms. Methods: Polyphenolic compounds of W.
Jayasingha Arachchige Chathuranga Chanaka Jayasingha, Kyoung Tae Lee, Cheng-Yun Jin, Yung Hyun Choi, Chang Soo Lee, Min-Jeong Jung, Gi-Young Kim   +6 more
doaj   +1 more source

IGF-1 enhances the osteogenic activity of BMP-6 in vitro and in vivo [PDF]

, 2017
Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and alternatives are being explored.
Becerra-Ratia, Jose, Rico-Llanos, Gustavo Adolfo, Visser, Rick   +2 more
core