Results 141 to 150 of about 7,909,245 (408)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

Journal of Bone and Mineral Research, 2015
Hydrogen sulfide (H2S) is a gasotransmitter known to regulate bone formation and bone mass in unperturbed mice. However, it is presently unknown whether H2S plays a role in pathologic bone loss.
F. Grassi, A. M. Tyagi, John W. Calvert, L. Gambari, L. Walker, Mingcan Yu, J. Robinson, Jau-yi Li, G. Lisignoli, Chiara Vaccaro, Jonathan W. Adams, R. Pacifici   +11 more
semanticscholar   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The induction of bone formation by 3D-printed PLGA microsphere scaffolds in a calvarial orthotopic mouse model: a pilot study

Frontiers in Bioengineering and Biotechnology
Polymeric biodegradable microspheres are readily utilized to support targeted drug delivery for various diseases clinically. 3D printed tissue engineering scaffolds from polymer filaments with embedded microspheres or nanoparticles, as well as bulk ...
Roland M. Klar, James C. Cox, Claire J. Houchen, Naren Raja, Houssam Bouloussa, Stefan Lohfeld   +5 more
doaj   +1 more source

Close to the bone: investigations into bone tissue mineralisation and mechanobiology of osteoporosis

, 2012
Osteoporosis is a metabolic skeletal disease characterized by low bone mass, depleted micro-architecture and reduced strength. The public health costs of osteoporosis relate almost entirely to the fractures that are the clinical manifestation of the ...
Brennan, Meadhbh
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Efficacy of 3D-Printed Scaffolds in Guided Tissue Regeneration for Combined Endo-Perio Lesions: A Clinical and Radiographic Study

Journal of Pharmacy and Bioallied Sciences
Background: Combined endo-perio lesions (CEPLs) are one of the toughest problems in clinical dentistry because of complex causative factors and multi-rooted anatomical structures.
Anuj Singh Parihar, Nimisha Nandanan, Hiren H. Patadiya, Meetu Jain, Aishwarya Arya, Rashmi Laddha, Santosh Kumar   +6 more
doaj   +1 more source

Atorvastatin Promotes Bone Formation in Aged apoE–/– Mice through the Sirt1–Runx2 Axis [PDF]

, 2020
Wei Hong, Zhanying Wei, Zhaohui Qiu, Zheng Li, Chensheng Fu, Zhibin Ye, Xiaoya Xu   +6 more
openalex   +1 more source

Mineral maturity and crystallinity index are distinct characteristics of bone mineral [PDF]

, 2010
The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used.
Delmas, Pierre D., Delmas, Pierre, D., Boivin, Georges, Panczer, Gérard, Rey, Christian, Farlay, Delphine   +5 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source