Results 11 to 20 of about 1,355,503 (353)

Transcriptomic characterization of classical monocytes highlights the involvement of immuno-inflammation in bone erosion in Rheumatoid Arthritis

Frontiers in Immunology, 2023
IntroductionEvidence-based data suggest that under inflammatory conditions, classical monocytes are the main source of osteoclasts and might be involved in bone erosion pathophysiology.
Lucas Peixoto Sales, Bidossessi Wilfried Hounkpe, Mariana Ortega Perez, Valéria Falco Caparbo, Diogo Souza Domiciano, Eduardo Ferreira Borba, Georg Schett, Camille Pinto Figueiredo, Rosa Maria Rodrigues Pereira   +8 more
doaj   +1 more source

lncRNA MEG3 Suppresses the Progression of Ankylosis Spondylitis by Regulating the Let-7i/SOST Axis

Frontiers in Molecular Biosciences, 2020
Ankylosis spondylitis (AS) is a disease mainly characterized by sacroiliac joint and spinal attachment point inflammation. Long non-coding RNA (lncRNA) plays a key role in the progression of many diseases.
Junjie Ma, Xiaohua Zhang, Hongxing Zhang, Hailong Chen   +3 more
doaj   +1 more source

Effects of systemically administered abaloparatide, an osteoanabolic PTHrP analog, as an adjuvant therapy for spinal fusion in rats

JOR Spine, 2021
Background Abaloparatide is a parathyroid hormone receptor agonist that increases bone formation and reduces vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis.
Heike Arlt, Tatiana Besschetnova, Michael S. Ominsky, Douglas C. Fredericks, Beate Lanske   +4 more
doaj   +1 more source

A potential therapeutic drug for osteoporosis: prospect for osteogenic LncRNAs

Frontiers in Endocrinology, 2023
Long non-coding RNAs (LncRNAs) play essential roles in multiple physiological processes including bone formation. Investigators have revealed that LncRNAs regulated bone formation through various signaling pathways and micro RNAs (miRNAs).
Fanjin Meng, Fanjin Meng, Yang Yu, Ye Tian, Meng Deng, Meng Deng, Kaiyuan Zheng, Kaiyuan Zheng, Xiaolan Guo, Xiaolan Guo, Beilei Zeng, Jingjia Li, Airong Qian, Chong Yin, Chong Yin, Chong Yin   +15 more
doaj   +1 more source

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility.
Andreozzi, Anetzberger, Anichini, Aoyama, Baggio, Balint, Ban, Beckman, Bouxsein, Brunton, Chen, Coleman, Dempster, Ealey, Eckel, Feng, Flatt, Friedman, Griffith, Griffith, Hamilton, Hu, Karim, Kim, Lee, Lu, Ma, Mabilleau, Mabilleau, Mansur, Marenzana, Mieczkowska, Napoli, Nuche-Berenguer, Nuche-Berenguer, Nuche-Berenguer, Nystrom, Nystrom, Odgaard, Okerson, Orland, Orriss, Paschalis, Pereira, Pereira, Prisby, Richard, Roche, Roszer, Schalkwijk, Scheller, Selley, Shymkiw, Smits, Stabley, Sun, Tartaglia, Upadhyay, van Bloemendaal, Vijan, Williams, Wu, Yamamoto, Yamamoto, Yamamoto   +64 more
core   +6 more sources

Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation

FASEB BioAdvances, 2023
The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien, Michihiko Usui, William N. Addison, Takuma Matsubara, Tomohiko Shirakawa, Toshiyuki Tsujisawa, Keisuke Nakashima, Shoichiro Kokabu   +7 more
doaj   +1 more source

PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss

Frontiers in Endocrinology, 2023
PTH 1-34 (teriparatide) is approved by FDA for the treatment of postmenopausal osteoporosis. Iron overload is a major contributing factor for bone loss induced by unloading.
Jingmin Che, Jingmin Che, Weihao Ren, Weihao Ren, Weihao Ren, Xin Chen, Xin Chen, Fang Wang, Fang Wang, Gejing Zhang, Gejing Zhang, Peng Shang, Peng Shang   +12 more
doaj   +1 more source

A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling [PDF]

, 2010
In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilizing human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven.
Eyckmans, Jeroen, Luyten, F. P., Roberts, S. J., Schrooten, J.   +3 more
core   +1 more source

Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits [PDF]

, 2008
Background: Whereas various molecular working mechanisms of shock waves have been demonstrated, no study has assessed in detail the influence of varying energy flux densities (EFD) on new bone formation in vivo. Methods: Thirty Chinchilla bastard rabbits
Hausdorf, J., Maier, M., Milz, S., Pautke, C., Schmitz, C., Tischer, T., Weiler, C.   +6 more
core   +1 more source

Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal

Frontiers in Cell and Developmental Biology, 2020
Skeletal muscle and bone are highly interrelated, and previous proteomic analyses suggest that lumican is one of muscle-derived factors. To further understand the role of lumican as a myokine affecting adjacent bone metabolism, we investigated the ...
Jin Young Lee, So Jeong Park, Da Ae Kim, Seung Hun Lee, Jung-Min Koh, Beom-Jun Kim   +5 more
doaj   +1 more source