PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss
Frontiers in Endocrinology, 2023 PTH 1-34 (teriparatide) is approved by FDA for the treatment of postmenopausal osteoporosis. Iron overload is a major contributing factor for bone loss induced by unloading.
Jingmin Che +12 more
doaj +1 more source
Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial [PDF]
, 2018 Background Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding
Gillett, Ashley N. +3 more
core +1 more source
Genetic basis for skeletal new bone formation [PDF]
Exploration of Musculoskeletal Diseases, 2023 Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, including differentiation in osteoblasts, proliferation, matrix
Bruna Parreira +3 more
doaj +1 more source
Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
, 2019 Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
core +1 more source
Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]
, 2014 The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter +53 more
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Factors stimulating bone formation [PDF]
European Spine Journal, 2001 The aim of this review is to describe major approaches for stimulating bone healing and to review other factors affecting bone healing. Spinal bone fusion after surgery is a demanding process requiring optimal conditions for clinical success. Bone formation and healing can be enhanced through various methods. Experimental studies have revealed an array
Lind, Martin, Bünger, Cody
openaire +3 more sources
Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal
Frontiers in Cell and Developmental Biology, 2020 Skeletal muscle and bone are highly interrelated, and previous proteomic analyses suggest that lumican is one of muscle-derived factors. To further understand the role of lumican as a myokine affecting adjacent bone metabolism, we investigated the ...
Jin Young Lee +5 more
doaj +1 more source
Bone substitute effect on vascularization and bone remodeling after application of phVEGF165 transfected BMSC [PDF]
, 2012 VEGF (vascular endothelial growth factor) promotes vascularization and remodeling of bone substitutes. The aim of this study was to examine the effect of distinct resorbable ceramic carriers on bone forming capacities of VEGF transfected bone marrow ...
Beverungen, Mirjam +5 more
core +2 more sources
Frontiers in Pharmacology, 2021 Postmenopausal osteoporosis is a disease of bone mass reduction and structural changes due to estrogen deficiency, which can eventually lead to increased pain and fracture risk. Chronic inflammatory microenvironment leading to the decreased activation of
Gaoran Ge +10 more
doaj +1 more source
Biomimetic bone-like apatite coating on anodised titanium in simulated body fluid under UV irradiation [PDF]
, 2017 Low temperature deposition techniques of bioceramics coatings are now being researched and developed to avoid deficiencies inherent in high temperature techniques.
Chandrasekar Ramasamy, Chandrasekar Ramasamy +4 more
core +1 more source