Results 11 to 20 of about 7,909,245 (408)

The Bone Extracellular Matrix in Bone Formation and Regeneration [PDF]

Frontiers in Pharmacology, 2020
Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties.
Xiao Lin, Suryaji Patil, Yong-Guang Gao, Airong Qian   +3 more
openaire   +4 more sources

RANKL-induced M1 macrophages are involved in bone formation

Bone Research, 2017
The activation of M1 macrophages can be achieved by stimulating them with lipopolysaccharide (LPS) and interferon-γ (IFN-γ). However, M1 can be found under physiological conditions without any pathological stimuli.
Xin Wang, Yinghong Zhou, Huang, Rong, Zhou, Yinghong, Wang, Xin, Xiao, Yin, Yin Xiao, Rong Huang   +7 more
core   +2 more sources

Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation

Nature Communications, 2022
Sclerostin negatively regulates bone formation by antagonizing Wnt signalling. An antibody targeting sclerostin for the treatment of postmenopausal osteoporosis was approved by the U.S.
Yuanyuan Yu, Luyao Wang, Shuaijian Ni, Di-Jie Li, Jin Liu, H. Chu, Ning Zhang, Meiheng Sun, N. Li, Qing Ren, Zhenjian Zhuo, Chuanxin Zhong, Duoli Xie, Yongshu Li, Zongkang Zhang, Huarui Zhang, Mei Li, Zhenlin Zhang, Lin Chen, Xiao-hua Pan, W. Xia, Shu Zhang, Aiping Lu, Bao-Ting Zhang, Ge Zhang   +24 more
semanticscholar   +1 more source

Bisphosphonates impair the onset of bone formation at remodeling sites.

Bone, 2021
Bisphosphonates are widely used anti-osteoporotic drugs targeting osteoclasts. They strongly inhibit bone resorption, but also strongly reduce bone formation.
P. R. Jensen, T. L. Andersen, P. Chavassieux, J. Roux, J. Delaissé   +4 more
semanticscholar   +1 more source

Growth factors in the initial stage of bone formation, analysis of their expression in chondrocytes from epiphyseal cartilage of rat costochondral junction

Folia Histochemica et Cytobiologica, 2021
INTRODUCTION: In endochondral ossification septoclasts and osteoclasts (also called chondroclasts) release growth factors deposited in non-calcified and calcified zones of the growth plate.
Anna Hyc, Stanislaw Moskalewski, Anna Osiecka-Iwan   +2 more
doaj   +1 more source

A Novel Variant in CLCN7 Regulates the Coupling of Angiogenesis and Osteogenesis

Frontiers in Cell and Developmental Biology, 2020
Autosomal dominant osteopetrosis type II (ADO II), characterized by increased bone mass and density, is caused by mutations in the chloride channel 7 (CLCN7) gene.
Hui Peng, Hong-Bo He, Ting Wen
doaj   +1 more source

Experimental Study on the Influence of Apigenin K and Melatonin in Socket Preservation as Bone Stimulators: An Experimental Study in Beagle Dogs

Applied Sciences, 2020
The aim is to evaluate whether apigenin K and melatonin M5250 were able to stimulate bone formation after tooth extraction at one, two, and three months follow-up. Six male beagle dogs were used.
José Luis Calvo-Guirado, Manuel Fernández-Domínguez, Juan Manuel Aragoneses, Enrique Fernández-Bodereau, Miguel Angel Garcés-Villalá, Felix De Carlos-Villafranca, Manuel Cabello-Colás, Rocío Jiménez-López, Carlos Pérez Albacete-Martínez, Rafael Arcesio Delgado-Ruiz   +9 more
doaj   +1 more source

LABORATORY ASPECTS AND CLINICAL SIGNIFICANCE OF BONE TURNOVER MARKERS [PDF]

Annals of Mechnikov's Institute, 2019
Introduction. With an aging population, there is a marked increase in prevalence of metabolic bone diseases, especially osteoporosis. A serious complication of osteoporosis is non-traumatic bone fractures, which significantly impair quality of life and ...
Yehudina, Ye.D., Golovach, I.Yu.
doaj   +1 more source

Regenerative Healing of Chitosan Scaffold Impregnated with Simvastatin in Repairing Furcal Perforation

Applied Sciences, 2021
This study aimed to evaluate the healing of furcation when repaired with Chitosan (CS) scaffold impregnated or not with Simvastatin (SIM) compared with CollaCote (CL) in goat premolar teeth.
Ghaliah M. Alsawah, Manal Alsheddi, Ebtissam M. Al-Madi, Mohammad I. Al-Obaida   +3 more
doaj   +1 more source

Effect of Injectable platelet-rich fibrin (i-PRF) on new bone formation in surgical expansion with mini-screw assisted rapid palatal expander: A dog model study

Journal of Orthodontic Science, 2023
OBJECTIVES: The objective of the study is to test whether the local injection of i-PRF may affect osteoblast, blood vessels and new bone formation in surgically expanded mid palatal suture using maxillary skeletal expander.
Khawla M Awni, Zaid Dewachi, Osama Hazim Al-Hyani   +2 more
doaj   +1 more source