Results 11 to 20 of about 699,964 (265)
A potential therapeutic drug for osteoporosis: prospect for osteogenic LncRNAs
Frontiers in Endocrinology, 2023 Long non-coding RNAs (LncRNAs) play essential roles in multiple physiological processes including bone formation. Investigators have revealed that LncRNAs regulated bone formation through various signaling pathways and micro RNAs (miRNAs).
Fanjin Meng +15 more
doaj +1 more source
lncRNA MEG3 Suppresses the Progression of Ankylosis Spondylitis by Regulating the Let-7i/SOST Axis
Frontiers in Molecular Biosciences, 2020 Ankylosis spondylitis (AS) is a disease mainly characterized by sacroiliac joint and spinal attachment point inflammation. Long non-coding RNA (lncRNA) plays a key role in the progression of many diseases.
Junjie Ma +3 more
doaj +1 more source
JOR Spine, 2021 Background Abaloparatide is a parathyroid hormone receptor agonist that increases bone formation and reduces vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis.
Heike Arlt +4 more
doaj +1 more source
Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation
FASEB BioAdvances, 2023 The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien +7 more
doaj +1 more source
Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal
Frontiers in Cell and Developmental Biology, 2020 Skeletal muscle and bone are highly interrelated, and previous proteomic analyses suggest that lumican is one of muscle-derived factors. To further understand the role of lumican as a myokine affecting adjacent bone metabolism, we investigated the ...
Jin Young Lee +5 more
doaj +1 more source
VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo [PDF]
European Cells & Materials, 2010 Bone formation and osseointegration of biomaterials are dependent on angiogenesis and vascularization. Angiogenic growth factors such as vascular endothelial growth factor (VEGF) were shown to promote biomaterial vascularization and enhance bone ...
E Wernike +7 more
doaj
Frontiers in ImmunologyIt is well established that inflammatory processes in the vicinity of bone often induce osteoclast formation and bone resorption. Effects of inflammatory processes on bone formation are less studied.
Petra Henning +15 more
doaj +1 more source
PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss
Frontiers in Endocrinology, 2023 PTH 1-34 (teriparatide) is approved by FDA for the treatment of postmenopausal osteoporosis. Iron overload is a major contributing factor for bone loss induced by unloading.
Jingmin Che +12 more
doaj +1 more source
The Bone Extracellular Matrix in Bone Formation and Regeneration [PDF]
Frontiers in Pharmacology, 2020 Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties.
Xiao Lin +3 more
openaire +3 more sources