Results 31 to 40 of about 7,909,245 (408)

A potential therapeutic drug for osteoporosis: prospect for osteogenic LncRNAs

Frontiers in Endocrinology, 2023
Long non-coding RNAs (LncRNAs) play essential roles in multiple physiological processes including bone formation. Investigators have revealed that LncRNAs regulated bone formation through various signaling pathways and micro RNAs (miRNAs).
Fanjin Meng, Fanjin Meng, Yang Yu, Ye Tian, Meng Deng, Meng Deng, Kaiyuan Zheng, Kaiyuan Zheng, Xiaolan Guo, Xiaolan Guo, Beilei Zeng, Jingjia Li, Airong Qian, Chong Yin, Chong Yin, Chong Yin   +15 more
doaj   +1 more source

The Formation of Bone [PDF]

The American Journal of the Medical Sciences, 1882
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openaire   +1 more source

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]

, 2010
Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
Maronde, E. (Erik), Amling, Michael, Schinke, T. (Thorsten), Schilling, A.F. (Arndt), Schinke Thorsten, Seitz, S. (Sebastian), Albrecht Urs, Arndt F Schilling, Amling Michael, Urs Albrecht, Maronde, Erik, Schmutz, I. (Isabelle), Maronde Erik, Isabelle Schmutz, Horst, Gijsbertus van der, Thorsten Schinke, Schmutz Isabelle, Seitz, Sebastian, Schilling, Arndt F., Schilling Arndt F., Arndt F. Schilling, Seitz Sebastian, Schilling, Arndt, Sebastian Seitz, Schinke, Thorsten, Albrecht, U. (Urs), Schmutz, Isabelle, Amling, M. (Michael), Erik Maronde, Albrecht, Urs, Horst, G.T.J. (Gijsbertus) van der, Gijsbertus van der Horst, Michael Amling, van der Horst Gijsbertus   +33 more
core   +1 more source

lncRNA MEG3 Suppresses the Progression of Ankylosis Spondylitis by Regulating the Let-7i/SOST Axis

Frontiers in Molecular Biosciences, 2020
Ankylosis spondylitis (AS) is a disease mainly characterized by sacroiliac joint and spinal attachment point inflammation. Long non-coding RNA (lncRNA) plays a key role in the progression of many diseases.
Junjie Ma, Xiaohua Zhang, Hongxing Zhang, Hailong Chen   +3 more
doaj   +1 more source

Effects of systemically administered abaloparatide, an osteoanabolic PTHrP analog, as an adjuvant therapy for spinal fusion in rats

JOR Spine, 2021
Background Abaloparatide is a parathyroid hormone receptor agonist that increases bone formation and reduces vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis.
Heike Arlt, Tatiana Besschetnova, Michael S. Ominsky, Douglas C. Fredericks, Beate Lanske   +4 more
doaj   +1 more source

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.

Cell, 1997
A transcription factor, Cbfa1, which belongs to the runt-domain gene family, is expressed restrictively in fetal development. To elucidate the function of Cbfa1, we generated mice with a mutated Cbfa1 locus.
T. Komori, H. Yagi, S. Nomura, Akira Yamaguchi, Koichi Sasaki, Kenji Deguchi, Y. Shimizu, R. Bronson, Y.-H. Gao, Masahiko Inada, Makoto Sato, R. Okamoto, Yukihiko Kitamura, S. Yoshiki, T. Kishimoto   +14 more
semanticscholar   +1 more source

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

Bone Research, 2016
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling has fundamental roles in both embryonic skeletal development and postnatal bone homeostasis.
Mengrui Wu, Guiqian Chen, Yi-Ping Li
semanticscholar   +1 more source

Nobiletin, a NF‐κB signaling antagonist, promotes BMP‐induced bone formation

FASEB BioAdvances, 2023
The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation.
Thira Rojasawasthien, Michihiko Usui, William N. Addison, Takuma Matsubara, Tomohiko Shirakawa, Toshiyuki Tsujisawa, Keisuke Nakashima, Shoichiro Kokabu   +7 more
doaj   +1 more source

PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss

Frontiers in Endocrinology, 2023
PTH 1-34 (teriparatide) is approved by FDA for the treatment of postmenopausal osteoporosis. Iron overload is a major contributing factor for bone loss induced by unloading.
Jingmin Che, Jingmin Che, Weihao Ren, Weihao Ren, Weihao Ren, Xin Chen, Xin Chen, Fang Wang, Fang Wang, Gejing Zhang, Gejing Zhang, Peng Shang, Peng Shang   +12 more
doaj   +1 more source

Endothelialized tissue engineered 3D-construct for bone repair [PDF]

, 2005
One of the main problems arising when implanting a graft into a large bone gap is its insufficient vascularization in the central region. This results in impaired bone healing and often leads to necrosis in the graft.
Meury, Thomas
core   +1 more source