Results 51 to 60 of about 727,396 (265)

A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep

Journal of Functional Biomaterials, 2014
The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink®) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical
Marcella von Salis-Soglio, Stefan Stübinger, Michéle Sidler, Karina Klein, Stephen J. Ferguson, Käthi Kämpf, Katalin Zlinszky, Sabrina Buchini, Richard Curno, Péter Péchy, Bjorn-Owe Aronsson, Brigitte von Rechenberg   +11 more
doaj   +1 more source

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

eLife, 2021
Background: Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase iron availability for erythropoiesis.
Melanie Castro-Mollo, Sakshi Gera, Marc Ruiz-Martinez, Maria Feola, Anisa Gumerova, Marina Planoutene, Cara Clementelli, Veena Sangkhae, Carla Casu, Se-Min Kim, Vaughn Ostland, Huiling Han, Elizabeta Nemeth, Robert Fleming, Stefano Rivella, Daria Lizneva, Tony Yuen, Mone Zaidi, Yelena Ginzburg   +18 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Effective Oral Delivery of Teriparatide Using Organoclay—Polymethacrylate Nanocomposites for Osteoporosis Therapy

Pharmaceutics
Background: Although teriparatide is efficacious, its once-daily subcutaneous injections cause local adverse events, inconvenience, and higher cost, limiting long-term adherence.
Gyu Lin Kim, Yeon Ju Kang, Soo Hwa Seo, Jiwoon Jeon, Hyo-Kyung Han   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Could CH₃-M6P Be a Potential Dual-Functioning Candidate for Bone Regeneration?

Biomedicines
Background: CI-RM6P has different binding sites with affinities for both M6P and IGF2, plays a role in the regulation of the TGF-β and IGF pathways that is important for controlling cell growth and differentiation.
Fidan Huseynova, Cătălina Ionescu, Frederic Cuisinier, Irada Huseynova, Alamdar Mammadov, Véronique Barragan-Montero   +5 more
doaj   +1 more source

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Frontiers in Pharmacology, 2022
Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts.
Yan Li, Lingyu Li, Lingyu Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Li Han, Li Han, Ronghua Zhang, Ronghua Zhang, Ronghua Zhang, Huaqin Tian, Panpan Wang, Panpan Wang, Panpan Wang   +20 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Green Tea Extract Containing Epigallocatechin-3-Gallate Facilitates Bone Formation and Mineralization by Alleviating Iron-Overload-Induced Oxidative Stress in Human Osteoblast-like (MG-63) Cells

Antioxidants
Secondary iron overload exacerbates osteoporosis by elevating reactive oxygen species (ROS), which suppress osteoblast function and enhance osteoclast activity, disrupting bone remodeling.
Honghong Xu, Orawan Khantamat, Woranontee Korsieporn, Narisara Paradee, Jin Li, Yanping Zhong, Somdet Srichairatanakool, Pimpisid Koonyosying   +7 more
doaj   +1 more source